Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Shinsuke Inuki (Autor)

Buch | Softcover

106 Seiten

2016 | Softcover reprint of the original 1st ed. 2012
Springer Verlag, Japan
978-4-431-56110-1 (ISBN)

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The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) .- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol .- Chapter 3. Conclusions.

Erscheinungsdatum	27.06.2016
Reihe/Serie	Springer Theses
Zusatzinfo	XVI, 106 p.
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Technik
ISBN-10	4-431-56110-2 / 4431561102
ISBN-13	978-4-431-56110-1 / 9784431561101
Zustand	Neuware