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Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Shinsuke Inuki (Autor)

Buch | Hardcover

106 Seiten

2011 | 2012
Springer Verlag, Japan
978-4-431-54042-7 (ISBN)

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The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) .- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol .- Chapter 3. Conclusions.

Reihe/Serie	Springer Theses
Zusatzinfo	XVI, 106 p.
Verlagsort	Tokyo
Sprache	englisch
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
Schlagworte	allene cyclization • bioactive natural products • ergot alkaloid • functionalized heterocycles • naural products • Palladium • palladium-catalyzed cascade cyclization • palladium-catalyzed domino cyclization • total synthesis
ISBN-10	4-431-54042-3 / 4431540423
ISBN-13	978-4-431-54042-7 / 9784431540427
Zustand	Neuware