Metals in Cells (eBook)

Valeria Culotta, Robert A. Scott (Herausgeber)

eBook Download: EPUB

2013
John Wiley & Sons (Verlag)
978-1-118-63621-3 (ISBN)

Infos

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.

This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include:  regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to 'foreign' metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.

The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

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Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the metallome ] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "e;foreign"e; metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

Autor

Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry) Distinguished Research Professor, University of Georgia, USA. Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.

Textauszug

Contributors

Maud E.S. Achard

University of Queensland, St. Lucia, QLD, Australia Copper in Immune Cells

José M. Argüello

Worcester Polytechnic Institute, Worcester, MA, USA Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases

Michael Aschner

The Kennedy Center for Research on Human Development and the Molecular Toxicology Center, Nashville, TN, USA Manganese in Neurodegeneration

Daiana Silva Avila

Universidade Federal do Pampa, Uruguaiana, RS, Brazil Manganese in Neurodegeneration

Pritha Bagchi

Georgia Institute of Technology, Atlanta, GA, USA Fluorescent Probes for Monovalent Copper

Jude Beaudoin

Université de Sherbrooke, Sherbrooke, QC, Canada Copper Transport in Fungi

Marla J. Berry

University of Hawaii at Manoa, Honolulu, HI, USA Selenoproteins—Regulation

Florian Bittner

Braunschweig University of Technology, Braunschweig, Germany Mo Cofactor Biosynthesis and Crosstalk with FeS

Crysten E. Blaby-Haas

University of California, Los Angeles, CA, USA Sparing and Salvaging Metals in Chloroplasts

Eric S. Boyd

Montana State University, Bozeman, MT, USA [FeFe]-Hydrogenase Cofactor Assembly

Jeff M. Boyd

Rutgers University, New Brunswick, NJ, USA Fe–S Cluster Biogenesis in Archaea and Bacteria

Joan B. Broderick

Montana State University, Bozeman, MT, USA [FeFe]-Hydrogenase Cofactor Assembly

Ashley I. Bush

University of Melbourne, Parkville, VIC, Australia Copper in Brain and Neurodegeneration

Amanda S. Byer

Montana State University, Bozeman, MT, USA [FeFe]-Hydrogenase Cofactor Assembly

Clara Camaschella

Vita-Salute University and San Raffaele Scientific Institute, Milano, Italy Hepcidin Regulation of Iron Homeostasis

Kyle P. Carter

University of Colorado, Boulder, CO, USA Fluorescent Zinc Sensors

Jennifer S. Cavet

University of Manchester, Manchester, UK Metals in Bacterial Pathogenicity and Immunity

Harsimranjit K. Chahal

Rutgers University, New Brunswick, NJ, USA Fe–S Cluster Biogenesis in Archaea and Bacteria

Paul A. Cobine

Auburn University, Auburn, AL, USA Copper in Mitochondria

Jessica M. Collins

Worcester Polytechnic Institute, Worcester, MA, USA Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases

Colin Correnti

Fred Hutchinson Cancer Research Center, Seattle, WA, USA Iron Sequestration in Immunity

Joao Batista Teixeira da Rocha

Universidade Federal de Santa Maria, Santa Maria, RS, Brazil Manganese in Neurodegeneration

Andrew Dancis

University of Pennsylvania, Philadelphia, PA, USA Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters

Karrera Y. Djoko

University of Queensland, St. Lucia, QLD, Australia Copper in Immune Cells

David J. Eide

University of Wisconsin-Madison, Madison, WI, USA Zinc Transporters and Trafficking in Yeast

Thomas Eitinger

Humboldt-Universität zu Berlin, Berlin, Germany Transport of Nickel and Cobalt in Prokaryotes

Christoph J. Fahrni

Georgia Institute of Technology, Atlanta, GA, USA Fluorescent Probes for Monovalent Copper

Adrian G. Flores

Northwestern University, Evanston, IL, USA Structural Biology of Copper Transport

Andrew W. Foster

University of Durham, Durham, UK Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis

David P. Giedroc

Indiana University, Bloomington, IN, USA Metal Specificity of Metallosensors

Benjamin A. Gilston

Northwestern University, Evanston, IL, USA Mechanisms Controlling the Cellular Metal Economy

Vadim N. Gladyshev

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA The Metallome

Mary Lou Guerinot

Dartmouth College, Hanover, NH, USA Iron in Plants

John D. Helmann

Cornell University, Ithaca, NY, USA Metal Homeostasis and Oxidative Stress in Bacillus subtilis

Khadine A. Higgins

Indiana University, Bloomington, IN, USA Metal Specificity of Metallosensors

Yilin Hu

University of California, Irvine, CA, USA Nitrogenase Cofactor Assembly

Raphaël Ioannoni

Université de Sherbrooke, Sherbrooke, QC, Canada Copper Transport in Fungi

Michael D. Jones

University of Toronto, Toronto, ON, Canada NikR: Mechanism and Function in Nickel Homeostasis

Taiho Kambe

Kyoto University, Kyoto, Japan Regulation of Zinc Transport

Simon Labbé

Université de Sherbrooke, Sherbrooke, QC, Canada Copper Transport in Fungi

Chi Chung Lee

University of California, Irvine, CA, USA Nitrogenase Cofactor Assembly

Jaekwon Lee

University of Nebraska-Lincoln, Lincoln, NE, USA Cadmium Transport in Eukaryotes

Jeffrey R. Liddell

University of Melbourne, Parkville, VIC, Australia Copper in Brain and Neurodegeneration

Paul A. Lindahl

Texas A&M University, College Station, TX, USA Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters

Zijuan Liu

Oakland University, Rochester, MI, USA Resistance Pathways for Metalloids and Toxic Metals

Svetlana Lutsenko

Johns Hopkins University, Baltimore, MD, USA Copper Transporting ATPases in Mammalian Cells

Zhen Ma

Cornell University, Ithaca, NY, USA Metal Homeostasis and Oxidative Stress in Bacillus subtilis

Alastair G. McEwan

University of Queensland, St. Lucia, QLD, Australia Copper in Immune Cells

Ralf R. Mendel

Braunschweig University of Technology, Braunschweig, Germany Mo Cofactor Biosynthesis and Crosstalk with FeS

Sabeeha S. Merchant

University of California, Los Angeles, CA, USA Sparing and Salvaging Metals in Chloroplasts

Jose G. Miranda

University of Colorado, Boulder, CO, USA Fluorescent Zinc Sensors

M. Thomas Morgan

Georgia Institute of Technology, Atlanta, GA, USA Fluorescent Probes for Monovalent Copper

Mark R. O'Brian

State University of New York at Buffalo, Buffalo, NY, USA Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related -Proteobacteria

Thomas V. O'Halloran

Northwestern University,...

Produkt-Details

• Erscheint lt. Verlag: 30.12.2013
• Reihe/Serie: EIC Books
• Reihe/Serie: EIC Books
• Reihe/Serie: EIC Books
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Anorganische Chemie
• Themenwelt: Technik
• Schlagworte: Bioanorganische Chemie • Biochemical • bioinorganic chemistry • Biology • biomolecules • Biowissenschaften • Bound • Cell & Molecular Biology • characterized • Chemie • Chemistry • Drugs • Elements • Enzymes & Receptors • Enzyme u. Rezeptoren • Explosive • First • Function • Functions • growth • halfcentury • inorganic • Last • Life Sciences • metalcontaining • metals • Parallel • proteins • result • Role • Structures • tightly • Zell- u. Molekularbiologie
• ISBN-10: 1-118-63621-X / 111863621X
• ISBN-13: 978-1-118-63621-3 / 9781118636213