Manual of Molecular Microbiology (eBook)

Fundamentals and Applications

Randall T. Hayden, Karen C. Carroll, John P. Dekker, Alexander J. McAdam, Donna M. Wolk (Herausgeber)

eBook Download: EPUB

2025
1956 Seiten
ASM Press (Verlag)
978-1-68367-458-0 (ISBN)

Infos

Your essential guide to design, operation, management, and health care integration of the modern molecular microbiology laboratory

This comprehensive resource offers definitive guidance on the operational and interpretive aspects of clinical molecular microbiology. Tailored for medical laboratory professionals, it provides practical 'how-to' guidance for establishing, maintaining, and advancing molecular microbiology testing services and details the unique expertise required to support infectious disease diagnostics.

The Manual offers a clear and practical roadmap for topics ranging from selecting appropriate technologies, instruments, and analytic pipelines to navigating complex interpretive challenges and positioning diagnostic testing services for future clinical and population health needs.

Beginning with foundational technologies and their clinical applications, this book offers accessible overviews of each method's potential, implications, and emerging roles. Subsequent sections dive meticulously into details of laboratory setup, design, and operations, empowering readers with hands-on insights for routine and advanced testing methods, including advanced sequencing technologies. It also tackles the nuanced challenges of interpreting and reporting results from cutting-edge diagnostics, including those focused on antimicrobial resistance and metagenomics.

The final section explores the broader impact of molecular microbiology on value-based care, with discussions on clinical management, laboratory stewardship, and the future of molecular diagnostics in public health.

Comprehensive and forward-looking, the Manual of Molecular Microbiology equips readers with both foundational knowledge and practical expertise, making it an indispensable reference for today's clinical laboratory professionals.

Randall T. Hayden, St. Jude Children's Research Hospital, Memphis, TN, USA.

Karen C. Carroll, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

John P. Dekker, National Institutes of Health, Bethesda, MD, USA.

Alexander J. McAdam, Boston Children's Hospital, Boston, MA, USA.

Donna M. Wolk, Geisinger, Diagnostic Medicine Institute, Danville, PA; The Geisinger Commonwealth School of Medicine, Scranton, PA, USA.

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Your essential guide to the design, operation, management, and health care integration of the modern molecular microbiology laboratory. This comprehensive resource offers definitive guidance on the operational and interpretive aspects of clinical molecular microbiology. Tailored for medical laboratory professionals, it provides practical how-to guidance for establishing, maintaining, and advancing molecular microbiology testing services and details the unique expertise required to support infectious disease diagnostics. The Manual offers a clear and practical roadmap for topics ranging from selecting appropriate technologies, instruments, and analytic pipelines to navigating complex interpretive challenges and positioning diagnostic testing services for future clinical and population health needs. Beginning with foundational technologies and their clinical applications, this book offers accessible overviews of each method's potential, implications, and emerging roles. Subsequent sections dive meticulously into details of laboratory setup, design, and operations, empowering readers with hands-on insights for routine and advanced testing methods, including advanced sequencing technologies. It also tackles the nuanced challenges of interpreting and reporting results from cutting-edge diagnostics, including those focused on antimicrobial resistance and metagenomics. The final section explores the broader impact of molecular microbiology on value-based care, with discussions on clinical management, laboratory stewardship, and the future of molecular diagnostics in public health. Comprehensive and forward-looking, the Manual of Molecular Microbiology equips readers with both foundational knowledge and practical expertise, making it an indispensable reference for today's clinical laboratory professionals.

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Contributors

HEGE VANGSTEIN AAMOT
Section for Research and Development,
Department of Microbiology and Infection Control,
Akershus University Hospital,
Lørenskog, Norway;
Department of Nursing, Health and Laboratory Science,
Faculty of Health, Welfare and Organization,
Østfold University College,
Fredrikstad, Norway

MELIS N. ANAHTAR
Department of Pathology,
Department of Medicine,
Division of Infectious Diseases,
Massachusetts General Hospital,
Boston, MA;
Infectious Diseases and Microbiome Program,
Broad Institute of MIT and Harvard,
Cambridge, MA

NEIL W. ANDERSON
Department of Pathology,
University Hospitals Health System,
Case Western School of Medicine,
Cleveland, OH

ROI AVRAHAM
Department of Immunology and Regenerative Biology,
Weizmann Institute of Science,
Rehovot, Israel

N. ESTHER BABADY
Clinical Microbiology Service,
Infectious Disease Service,
Department of Pathology and Laboratory Medicine,
Memorial Sloan Kettering Cancer Center
New York, NY

ALLEN BATEMAN
Communicable Disease Division,
Wisconsin State Laboratory of Hygiene,
Madison, WI

SUSAN M. BENSON
School of Population Health,
Curtin University,
Perth, Australia

SARA J. BLOSSER
Goldbelt Professional Services, LLC
Atlanta, GA

JERRY BOONYARATANAKORNKIT
Research and Development, Fort Worth Diagnostics,
Fort Worth, TX

BLAKE W. BUCHAN
Department of Pathology,
The Medical College of Wisconsin and Children’s
Wisconsin,
Milwaukee, WI

ARRYN CRANEY
MiraVista Diagnostics,
Indianapolis, IN;
Petrified Bugs, LLC,
Miami, FL

AUGUSTO DULANTO CHIANG
Department of Infectious Diseases,
Vanderbilt University Medical Center,
Nashville, TN

JAMES J. DUNN
Department of Pathology,
Texas Children's Hospital;
Department of Pathology & Immunology,
Baylor College of Medicine,
Houston, TX

RUBEN DYRHOVDEN
Department of Microbiology,
Haukeland University Hospital,
Bergen, Norway

ADRIAN EGLI
Institute of Medical Microbiology,
University of Zurich,
Zurich, Switzerland

DAVID C. GASTON
Department of Pathology, Microbiology, and Immunology,
Vanderbilt University Medical Center,
Nashville, TN

HEATHER L. GLASGOW
Department of Pathology,
St. Jude Children’s Research Hospital,
Memphis, TN

SWATHI GOWTHAM
Pediatric Infectious Diseases,
Geisinger Medical Center,
Danville, PA

ERIN H. GRAF
Department of Laboratory Medicine and Pathology,
Mayo Clinic Arizona,
Phoenix, AZ

JOCELYN HAUSER
Public Health Laboratory,
DC Department of Forensic Science,
Washington, DC

JULIE HIRSCHHORN
Laboratory Medicine,
Geisinger,
Danville, PA

JIM F. HUGGETT
National Measurement Laboratory, LGC,
Teddington, Middlesex;
School of Biosciences & Medicine,
University of Surrey,
Guildford
United Kingdom

ROMNEY HUMPHRIES
Department of Pathology, Microbiology and Immunology,
Vanderbilt University Medical Center,
Nashville TN

KATRINA KALANTAR
Chan Zuckerberg Initiative, Science,
Redwood City, CA

HALUK KAVUS
Laboratory Medicine,
Geisinger,
Danville, PA

ØYVIND KOMMEDAL
Department of Microbiology,
Haukeland University Hospital,
Bergen, Norway

LYDIA A. KRASILNIKOVA
Infectious Diseases and Microbiome Program,
Broad Institute of MIT and Harvard,
Cambridge, MA;
Howard Hughes Medical Institute,
Chevy Chase, MD

CHARLES R. LANGELIER
Division of Infectious Diseases,
Department of Medicine,

University of California San Francisco;
Chan Zuckerberg Biohub,
San Francisco, CA

PAIGE M.K. LARKIN
American Society for Microbiology,
Washington, DC

HUANG LIN
Department of Epidemiology and Biostatistics,
University of Maryland,
College Park, MD

BENJAMIN M. LIU
Division of Pathology and Laboratory Medicine,
Children’s National Hospital;
Department of Pediatrics,
Department of Pathology,
Department of Microbiology, Immunology and Tropical
Medicine,
The George Washington University School of
Medicine and Health Sciences;
Children’s National Research Institute;
The District of Columbia Center for AIDS Research,
Washington, DC

S. WESLEY LONG
Houston Methodist Hospital,
Department of Pathology & Genomic Medicine,
Houston, TX

EMILY C. LYDON
Division of Infectious Diseases,
Department of Medicine,
University of California San Francisco,
San Francisco, CA

REBEKAH M. MARTIN
BD Life Sciences–Integrated Diagnostic Solutions,
Becton, Dickinson and Company,
Winnersh, United Kingdom

AMY J. MATHERS
Department of Medicine and Pathology,
Division of Infectious Diseases and International Health,
University of Virginia,
Charlottesville, VA

NINAD MEHTA
Division of Clinical Microbiology,
Royal University Hospital & Saskatchewan Health Authority;

Department of Pathology & Laboratory
Medicine, College of Medicine,
University of Saskatchewan,
Saskatoon, SK, Canada

ASUNCION MEJIAS
Department of Infectious Diseases,
St. Jude Children’s Research Hospital,
Memphis, TN

ALEXANDER MELLMANN
Institute of Hygiene,
University Hospital Muenster,
University of Muenster;
National Consulting Laboratory for Hemolytic Uremic
Syndrome (HUS);
National Reference Center for Clostridioides difficile,
Muenster Branch,
Muenster, Germany

STEVE MILLER
Delve Bio;
Department of Laboratory Medicine,
University of California San Francisco,
San Francisco, CA

ABRAHAM G. MOLLER
Bacterial Pathogenesis and Antimicrobial Resistance Unit,
National Institute of Allergy and Infectious Diseases,
National Institutes of Health,
Bethesda, MD

JACOB MORAN‐GILAD
School of Public Health,
Faculty of Health Sciences,
Ben Gurion University of the Negev,
Beer Sheva, Israel;
Department of Clinical Microbiology and Infectious
Diseases,
Hadassah Medical Center,
Jerusalem, Israel

JAMES T. MORTON
G&A,
Gutz Analytics,
Boulder, CO

HEBA H. MOSTAFA
Department of Pathology,
Division of Medical Microbiology,
The Johns Hopkins School of Medicine,
Baltimore, MD

BRIAN O’DONOVAN
Delve Bio,
San Francisco, CA

DANIEL A. ORTIZ
Department of Microbiology,
Labcorp,
Royal Oak, MI

DENISE M. O’SULLIVAN
National Measurement Laboratory, LGC,
Teddington, Middlesex;
School of Biosciences & Medicine,
University of Surrey,
Guildford
United Kingdom

BIJAL A. PARIKH
Department of Pathology and Immunology,
Washington University School of Medicine,
St. Louis, MO

ELEANOR POWELL
Microbiology and Molecular Diagnostics Laboratory,
Department of Pathology and Laboratory Medicine,
University of Cincinnati,
Cincinnati, OH

OCTAVIO RAMILO
Department of Infectious Diseases,
St. Jude Children’s Research Hospital,
Memphis, TN

KYLE G. RODINO
Department of Pathology and Laboratory Medicine,
Perelman School of Medicine, University of Pennsylvania,
Philadelphia, PA

ASHLEY M. ROONEY
Institute of Medical Microbiology,
University of Zurich,
Zurich, Switzerland

JOHN W. A. ROSSEN
Laboratory of Medical Microbiology and Infectious Diseases &
Isala Academy,
Isala Hospital,
Zwolle, Netherlands;
Department of Medical Microbiology and Infection Control,
University of Groningen,
University Medical Center Groningen,
Groningen, The Netherlands;
Department of Pathology,
University of Utah School of Medicine,
Salt Lake City, UT

JONATHAN SANDERS
G&A,
Lightweight Labware,
Santa Cruz, CA

MOHAMAD R. A. SATER
Day Zero Diagnostics,
Watertown, MA;
Department of Immunology and Infectious Diseases,
Harvard T.H Chan School of Public Health,
Boston, MA

NATALIE SCHERFF
Institute of Hygiene,
University Hospital Muenster,
University of Muenster,
Muenster, Germany

ROBERT SCHLABERG
Illumina, Inc.,
Salt Lake City, UT

HELENA M.B. SETH‐SMITH
Institute of Medical Microbiology,
University of Zurich,
Zurich, Switzerland

PATRICIA J. SIMNER
Department of Pathology,
Division of Medical Microbiology,
The Johns Hopkins School of Medicine,
Baltimore, MD

DEREK D. N. SMITH
Ecotoxicology and Wildlife Health Division,
Wildlife and Landscape Science Directorate,
Environment and Climate Change Canada,
Ottawa, Ontario, Canada

ARYEH SOLOMON
Department of Immunology and Regenerative Biology,
Weizmann Institute of Science,
Rehovot, Israel

MEGHAN W. STAROLIS
Department of Molecular Infectious Disease,
Quest Diagnostics,
Chantilly, VA

NEERAJ K. SURANA
Department of Pediatrics,
Department of Molecular Genetics and Microbiology,
Department of Integrative Immunobiology,
Department of Cell Biology,
Duke Microbiome Center,
Duke University School of Medicine,
Durham, NC

CHIN YEE TAN
Department of Pediatrics,
Duke University School of Medicine,
Durham, NC;
Duke‐NUS Medical School,
Singapore;
Medicine Academic Clinical Programme,
Singapore Health...

Produkt-Details

• Erscheint lt. Verlag: 30.5.2025
• Reihe/Serie: ASM Books
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Schlagworte: molecular microbiology book • molecular microbiology interpretation • molecular microbiology lab design • molecular microbiology lab management • molecular microbiology lab operation • molecular microbiology operation • Molecular microbiology technologies
• ISBN-10: 1-68367-458-8 / 1683674588
• ISBN-13: 978-1-68367-458-0 / 9781683674580