Anti-fibrotic Drug Discovery (eBook)

Jehrod Brenneman, Malliga R Iyer (Herausgeber)

eBook Download: EPUB

2020
Rsc (Verlag)
9781839160516 (ISBN)

Infos

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Inhalt

TGFβ Signaling; Targeting the αv Integrins in Fibroproliferative Disease; Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators; Autotaxin Inhibitors in Fibrosis; Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology; Targeting the Ubiquitin Proteasome System in Pulmonary Fibrosis; Galectin-3 Involvement in Fibrotic Diseases; Emerging Role of CXCR4 in Fibrosis; BH3 Mimetic Drugs for Anti-fibrotic Therapy; Intratumoral Fibrosis: Emerging Concepts and Therapeutic Opportunities; Targeting Fibroblasts in Fibrosis and Cancer

Produkt-Details

• Erscheint lt. Verlag: 17.2.2020
• Reihe/Serie: Drug Discovery Series
• Reihe/Serie: ISSN
• Reihe/Serie: ISSN
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Freizeit / Hobby ► Sammeln / Sammlerkataloge
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Schlagworte: Andrew • Anne • Anti • Autotaxin Inhibitors • Bates • BH3 Mimetic Drugs • brenneman • constance • Cremasco • CXCR4 • Daniel • David • Desroy • Dieter • Discovery • Drug • Fibroproliferative Disease • Fibrosis • fibrotic • Fibrotic Pathology • Foley • galectin-3 • Hamprecht • Iyer • JAI • Jamie • Jehrod • John • Lagares • Lysyl Oxidase Enzymes • Malliga • Merk • Michael • Nicolas • Prakash • R • Robert • Rotella • Slack • TGF Beta signaling • Thorley • Thurston • Trendelenburg • Ulrike • Viviana
• ISBN-13: 9781839160516 / 9781839160516