Systems Biology (eBook)

Jens Nielsen, Stefan Hohmann, Sang Yup Lee, J. Nielsen, Gregory Stephanopoulos (Herausgeber)

eBook Download: EPUB

2017 | 1. Auflage
432 Seiten
Wiley-Blackwell (Verlag)
978-3-527-69617-8 (ISBN)

Infos

Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems.

Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression.

This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.

Jens Nielsen has a PhD degree (1989) in Biochemical Engineering from the Danish Technical University (DTU), and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU he founded and directed the Center for Microbial Biotechnology. In 2008 he was recruited as Professor and Director to Chalmers University of Technology, Sweden. Jens Nielsen has received numerous Danish and international awards including the Nature Mentor Award, and is member of several academies, including the National Academy of Engineering in USA and the Royal Swedish Academy of Science. He is a founding president of the International Metabolic Engineering Society.

Stefan Hohmann is Head of the Department of Biology and Biological Engineering at Chalmers University (Sweden). He studied biology and microbiology at the Technische Universitat Darmstadt (Germany), where he received his PhD in 1987 and became professor in 1993. He held positions as visiting professor at the Katholieke Universiteit Leuven (Belgium) and the University of the Orange Free State (South Africa), before joining the University of Gothenburg in 1999 as professor, a position he hold until his change to Chalmers University in 2015. Stefan Hohmann serves as chairman of several committees and is the Swedish representative at the European Molecular Biology Laboratory (EMBL) Research Council.

Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He is currently the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award and the Elmer Gaden Award. Lee is the Editor-in-Chief of the Biotechnology Journal and Associate Editor and board member of numerous other journals. Lee is currently serving as a member of Presidential Advisory Committee on Science and Technology (Korea).

Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.

Autor

Jens Nielsen has a PhD degree (1989) in Biochemical Engineering from the Danish Technical University (DTU), and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU he founded and directed the Center for Microbial Biotechnology. In 2008 he was recruited as Professor and Director to Chalmers University of Technology, Sweden. Jens Nielsen has received numerous Danish and international awards including the Nature Mentor Award, and is member of several academies, including the National Academy of Engineering in USA and the Royal Swedish Academy of Science. He is a founding president of the International Metabolic Engineering Society. Stefan Hohmann is Head of the Department of Biology and Biological Engineering at Chalmers University (Sweden). He studied biology and microbiology at the Technische Universität Darmstadt (Germany), where he received his PhD in 1987 and became professor in 1993. He held positions as visiting professor at the Katholieke Universiteit Leuven (Belgium) and the University of the Orange Free State (South Africa), before joining the University of Gothenburg in 1999 as professor, a position he hold until his change to Chalmers University in 2015. Stefan Hohmann serves as chairman of several committees and is the Swedish representative at the European Molecular Biology Laboratory (EMBL) Research Council. Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He is currently the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award and the Elmer Gaden Award. Lee is the Editor-in-Chief of the Biotechnology Journal and Associate Editor and board member of numerous other journals. Lee is currently serving as a member of Presidential Advisory Committee on Science and Technology (Korea). Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.

Inhalt

1. Integrative Analysis of Omics Data
2. 13C Flux Analysis in Biotechnology and Medicine
3. Metabolic Modeling for Design of Cell Factories
4. Genome-Scale Metabolic Modeling and in silico Strain Design of Escherichia coli
5. Accelerating the Drug Development Pipeline with Genome-Scale Metabolic Reconstruction
6. Computational Modeling of Microbial Communities
7. Drug Targeting of the Human Microbiome
8. Towards Genome-Scale Models of Signal Transduction Networks
9. Systems Biology of Ageing
10. Modeling the Dynamics of the Immune Response
11. Dynamics of Signal Transduction in Single Cells Quantified by Microscopy
12. Image-Based in silico Models of Organogenesis
13. Progress Towards Quantitative Design Principles of Multicellular Systems
14. Precision Genome Editing for Systems Biology - A Temporal Perspective

Textauszug

List of Contributors

Elena Abad

Universitat Pompeu Fabra

Departament de Ciències Experimentals i de la Salut

Barcelona Biomedical Research Park

Dr. Aiguader 88

08003 Barcelona

Spain

and

IDIBAPS-Hospital Clínic

Center for Neuroimmunology

Barcelona

Spain

Johannes Borgqvist

Chalmers University of Technology and the University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

Siu H. J. Chan

The Pennsylvania State University

Department of Chemical Engineering

112 Fenske Laboratory

University Park, PA 16802

USA

Matthew W. Chang

National University of Singapore

Yong Loo Lin School of Medicine, Department of Biochemistry

8 Medical Drive

Singapore 117597

Singapore

and

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

Yi Ern Cheah

Vanderbilt University

Department of Chemical and Biomolecular Engineering

Nashville, TN 37235

USA

Marija Cvijovic

Chalmers University of Technology and University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

Riccardo Dainese

Chalmers University of Technology and the University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

and

École Polytechnique Fédérale de Lausanne (EPFL)

Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences

Lausanne

Switzerland

Bonnie V. Dougherty

University of Virginia

Department of Biomedical Engineering

415 Lane Road

Charlottesville, VA 22908

USA

Jee L. Foo

National University of Singapore

Yong Loo Lin School of Medicine, Department of Biochemistry

8 Medical Drive

Singapore 117597

Singapore

and

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

Jordi García-Ojalvo

Universitat Pompeu Fabra

Departament de Ciències Experimentals i de la Salut

Barcelona Biomedical Research Park

Dr. Aiguader 88

08003 Barcelona

Spain

Lada Georgieva

ETH Zurich

Department of Biosystems, Science and Engineering (D-BSSE), Swiss Institute of Bioinformatics (SIB)

Mattenstraße 26

4058 Basel

Switzerland

Harold F. Gómez

ETH Zurich

Department of Biosystems, Science and Engineering (D-BSSE), Swiss Institute of Bioinformatics (SIB)

Mattenstraße 26

4058 Basel

Switzerland

Diego R. Gomez-Alvarez

Chalmers University of Technology and University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

Sanjan T. P. Gupta

University of Wisconsin–Madison

Department of Chemical and Biological Engineering

3639 Engineering Hall

1415 Engineering Drive

Madison, WI 53706

USA

and

University of Wisconsin–Madison

Great Lakes Bioenergy Research Center

Madison, WI

USA

Clinton M. Hasenour

Vanderbilt University

Department of Chemical and Biomolecular Engineering

Nashville, TN 37235

USA

Dagmar Iber

ETH Zurich

Department of Biosystems, Science and Engineering (D-BSSE), Swiss Institute of Bioinformatics (SIB)

Mattenstraße 26

4058 Basel

Switzerland

Edda Klipp

Humboldt-Universität zu Berlin

Institute of Biology

Invalidenstr. 42

10115 Berlin

Germany

Marcus Krantz

Humboldt-Universität zu Berlin

Institute of Biology

Invalidenstr. 42

10115 Berlin

Germany

Erik Kristiansson

Chalmers University of Technology/University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

Prashant Kumar

University of Wisconsin–Madison

Department of Chemical and Biological Engineering

3639 Engineering Hall

1415 Engineering Drive

Madison, WI 53706

USA

Meiyappan Lakshmanan

Agency for Science, Technology and Research (A*STAR)

Bioprocessing Technology Institute

20 Biopolis Way, #06-01, Centros

Singapore 138668

Singapore

Dong-Yup Lee

Agency for Science, Technology and Research (A*STAR)

Bioprocessing Technology Institute

20 Biopolis Way, #06-01, Centros

Singapore 138668

Singapore

and

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

and

National University of Singapore

Department of Chemical and Biomolecular Engineering

4 Engineering Drive 4

Singapore 117585

Singapore

Na-Rae Lee

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

Rune Linding

University of Copenhagen (UCPH)

Biotech Research and Innovation Centre (BRIC)

Ole Maaløes Vej 5, 4

2200 Copenhagen

Denmark

Hua Ling

National University of Singapore

Yong Loo Lin School of Medicine, Department of Biochemistry

8 Medical Drive

Singapore 117597

Singapore

and

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

Timo Lubitz

Humboldt-Universität zu Berlin

Institute of Biology

Invalidenstr. 42

10115 Berlin

Germany

Min Ma

University of Lausanne

Department of Fundamental Microbiology

Biophore building

1015 Lausanne

Switzerland

Costas D. Maranas

The Pennsylvania State University

Department of Chemical Engineering

112 Fenske Laboratory

University Park, PA 16802

USA

Odysse Michos

ETH Zurich

Department of Biosystems, Science and Engineering (D-BSSE), Swiss Institute of Bioinformatics (SIB)

Mattenstraße 26

4058 Basel

Switzerland

Nadim Mira

University of Lausanne

Department of Fundamental Microbiology

Biophore building

1015 Lausanne

Switzerland

Thomas J. Moutinho Jr.

University of Virginia

Department of Biomedical Engineering

415 Lane Road

Charlottesville, VA 22908

USA

Ulrike Münzner

Humboldt-Universität zu Berlin

Institute of Biology

Invalidenstr. 42

10115 Berlin

Germany

Eduardo P. Olimpio

Delft University of Technology

Department of Bionanoscience, Kavli Institute of Nanoscience

Lorentzweg 1, Building 22

2628 CJ Delft

The Netherlands

Tobias Österlund

Chalmers University of Technology/University of Gothenburg

Department of Mathematical Sciences

Chalmers tvärgata 3

412 96 Gothenburg

Sweden

Jason Papin

University of Virginia

Department of Biomedical Engineering

415 Lane Road

Charlottesville, VA 22908

USA

Serge Pelet

University of Lausanne

Department of Fundamental Microbiology

Biophore building

1015 Lausanne

Switzerland

Jennifer L. Reed

University of Wisconsin–Madison

Department of Chemical and Biological Engineering

3639 Engineering Hall

1415 Engineering Drive

Madison, WI 53706

USA

and

University of Wisconsin–Madison

Great Lakes Bioenergy Research Center

Madison, WI

USA

Gourvendu Saxena

National University of Singapore

NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

and

National University of Singapore

Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Life Sciences Institute

28 Medical Drive

Singapore 117456

Singapore

and

National University of Singapore

Faculty of Science, Department of Biological...

Produkt-Details

• Erscheint lt. Verlag: 15.3.2017
• Reihe/Serie: Advanced Biotechnology
• Reihe/Serie: Advanced Biotechnology
• Reihe/Serie: Advanced Biotechnology
• Mitarbeit: Herausgeber (Serie): Sang Yup Lee, J. Nielsen, Gregory Stephanopoulos
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Analysis • Bioinformatics & Computational Biology • Bioinformatik • Bioinformatik u. Computersimulationen in der Biowissenschaften • biological • Biotechnologie • Biotechnologie i. d. Biowissenschaften • Biotechnologie i. d. Chemie • Biotechnology • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • constructing • contributors • Data • FluX • Gene • genes • Integration • Integrative • isotope tracers • Life Sciences • List • metabolic • Omics Data • platforms • References • series editors • Study • Systembiologie • Tobias • Zell- u. Molekularbiologie
• ISBN-10: 3-527-69617-2 / 3527696172
• ISBN-13: 978-3-527-69617-8 / 9783527696178