Neurodegeneration (eBook)

Anthony Schapira, Zbigniew K. Wszolek, Ted M. Dawson, Nicholas Wood (Herausgeber)

eBook Download: EPUB

2017
John Wiley & Sons (Verlag)
978-1-118-66191-8 (ISBN)

Infos

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.

• Presents a clinically oriented guide to the diseases caused by neurodegeneration 
• Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
• Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases 
• Edited by globally leading authorities on the subject, and written by expert contributing authors

About the Editors
Professor Anthony Schapira is Professor of Neurological Science and Head of the Department of Clinical Neuroscience at the UCL Institute of Neurology, London, UK and Chairman of Clinical Neurosciences Specialties.

Zbigniew Wszolek, MD, is Professor of Neurology in the Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

Ted M.Dawson, MD, PhD, is Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases and Scientific Director in the Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Professor Nicholas Wood is Research Director of the UCL Institute of Genetics and Galton Professor of Genetics at UCL National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK.

Inhalt

List of Contributors, vi

Preface, ix

Dedication, x

1 Pathology of Brain Aging, 1
Janna H. Neltner and Peter T. Nelson

2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12
Michel Goedert

3 Prion Degeneration, 25
James A. Mastrianni

4 Excitotoxicity, 37
Mark P. Mattson

5 Etiology and Pathogenesis of Parkinson Disease, 46
Ruth-Mary deSouza and Anthony H.V. Schapira

6 Parkinson Disease: Treatment Options - Surgical Therapy, 53
Travis S. Tierney and Andres M. Lozano

7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58
Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross

8 Progressive Supranuclear Palsy, 72
Huw R. Morris

9 Dementia with Lewy Bodies, 83
Rodolfo Savica and David S. Knopman

10 Corticobasal Degeneration, 93
Keith A. Josephs, Jr.

11 Alzheimer's Disease, 102
Qurat ul Ain Khan and Neill R. Graff-Radford

12 Frontotemporal Dementia, 115
Christian W. Wider, Barbara Jasinska-Myga, Takuya Konno, and Zbigniew K. Wszolek

13 Prion Diseases and Other Rapidly Progressive Dementias, 126
Eric Eggenberger and Daniel L. Murman

14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137
Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson

15 Hereditary Spastic Paraplegia, 161
Pawel P. Liberski and Craig Blackstone

16 Spinal Muscular Atrophy, 179
Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner

17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202
Erich Peter Bosch

18 Optic Neuropathies, 211
Desmond Kidd

19 Peripheral Nerve Neuropathies Including Charcot-Marie-Tooth Disease, 218
Amelie Pandraud and Henry Houlden

20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238
Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp

21 Huntington's Disease and Other Choreas, 248
Salman Haider, Edward Wild, and Sarah J. Tabrizi

22 Spinocerebellar Ataxias, 284
H. Brent Clark and Harry T. Orr

23 Ataxia Telangiectasia, 296
Malcolm Taylor

24 Niemann-Pick Disease, 303
Marc C. Patterson

25 X-linked Adrenoleukodystrophy, 309
Deborah L. Renaud

26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317
Alisdair McNeill

Index, 327

Textauszug

List of Contributors

 

Zeshan Ahmed, PhD
Research Fellow,
Department of Molecular Neuroscience,
UCL Institute of Neurology,
London, UK

Craig Blackstone, MD, PhD
Senior Investigator, Cell Biology Section, Neurogenetics Branch,
National Institutes of Neurological Disorders and Stroke,
National Institutes of Health,
Bethesda, Maryland, USA

Erich Peter Bosch, MD
Professor Emeritus of Neurology,
Department of Neurology,
Mayo Clinic Arizona,
Scottsdale, Arizona, USA

Kevin B. Boylan, MD
Associate Professor of Neurology,
Department of Neurology, Mayo Clinic,
Jacksonville, Florida, USA

Jacqueline Chen, PhD
Project Staff,
Department of Neuroscience,
Lerner Research Institute, Cleveland Clinic,
Cleveland, Ohio, USA

H. Brent Clark, MD, PhD
Professor,
Department of Laboratory Medicine and Pathology,
University of Minnesota Medical School,
Minneapolis, Minnesota, USA

Melissa E. Crowder, MD
Research Technician,
Department of Neurology,
Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA

Ruth-Mary deSouza, BSc, MBBS
Neurosurgery trainee and PhD student,
Institute of Neurology,
University College London,
London, UK

Dennis W. Dickson, MD
Robert E. Jacoby Professor of Alzheimer’s Research,
Department of Neuroscience, Mayo Clinic,
Jacksonville, Florida, USA

Ranjan Dutta, PhD
Assistant Staff,
Department of Neuroscience,
Lerner Research Institute, Cleveland Clinic,
Cleveland, Ohio, USA

Eric Eggenberger, DO
Professor,
Department of Neurology and Opthalmology,
Michigan State University,
East Lansing, Michigan, USA

Michel Goedert, MD, PhDMRC
Laboratory of Molecular Biology,
Francis Crick Avenue,
Cambridge, UK

Neill R. Graff-Radford, MBBCh, FRCP (Lond)
Professor of Neurology,
Mayo College of Medicine,
Jacksonville, Florida, USA

Salman Haider, BSc (Hons), MBBS, MRCP
Specialty Registrar in Neurology,
London Deanery,
Barking, Havering and
Redbridge University Hospitals NHS Trust,
Essex, UK

Henry Houlden, MD, PhD
Professor of Neurology and Neurogenetics and
MRC Centre for Neuromuscular Diseases,
Department of Molecular Neuroscience,
UCL Institute of Neurology,
Queen Square, London, UK

Barbara Jasinska-Myga, MD, PhD
Assistant Professor of Neurology,
Department of Neurology,
Medical University of Silesia,
Katowice, Poland

Keith A. Josephs, Jr., MD, MST, MSc
Professor of Neurology,
Department of Neurology,
Divisions of Movement Disorders and
Behavioral Neurology, Mayo Clinic Rochester,
Rochester, Minnesota, USA

Qurat ul Ain Khan, MD
Fellow, Mayo College of Medicine,
Jacksonville, Florida, USA

Desmond Kidd, MD, FRCP
Consultant Neurologist,
Department of Clinical Neurosciences and
Head, Department of Neuro-ophthalmology,
Royal Free Hospital, London, and
Honorary Senior Lecturer in Neurology,
University College London,
London, UK

David S. Knopman, MD
Professor of Neurology,
Department of Neurology,
Mayo Clinic Rochester, and Mayo Clinic Alzheimer's
Disease Research Center,
Rochester, Minnesota, USA

Takuya Konno, MD, PhD
Research Fellow,
Department of Neurology,
Mayo Clinic,
Jacksonville, Florida, USA

Pawel P. Liberski, MD, PhD
Professor and Chairman,
Departments of Molecular Pathology and
Neuropathology, Medical University of Lodz,
Lodz, Poland

Andres M. Lozano, OC, MD, PhD,
FRCSC, FRSC, FCAHS
University Professor and Dan Family Chairman of Neurosurgery,
Division of Neurosurgery,
University of Toronto,
Toronto Western Hospital,
Toronto, Ontario, Canada

James A. Mastrianni, MD, PhD
Professor of Neurology,
Director, Center for Comprehensive Care and
Research on Memory Disorders,
Department of Neurology, The University of Chicago,
Chicago, Illinois, USA

Mark P. Mattson, PhD
Chief,
Laboratory of Neurosciences,
National Institute on Aging Intramural Research Program,
Baltimore, Maryland, USA

Alisdair McNeill, PhD, MRCP (UK)
Senior Clinical Fellow,
Sheffield Institute of Translational Neuroscience (SITraN), Sheffield,
South Yorkshire, UK

Huw R. Morris, FRCP, PhD
Professor of Clinical Neuroscience,
Department of Clinical Neuroscience,
UCL Institute of Neurology,
London, UK

Daniel L. Murman, MD, MS
Director, Behavioral and Geriatric Neurology Program,
Professor, Department of Neurological Sciences,
University of Nebraska Medical Center,
Omaha, Nebraska, USA

Peter T. Nelson, MD, PhD
Professor of Pathology,
Department of Pathology,
Division of Neuropathology,
University of Kentucky and Sanders-Brown Center on Aging,
Lexington, Kentucky, USA

Janna H. Neltner, MD
Associate Professor of Pathology,
Department of Pathology,
Division of Neuropathology,
University of Kentucky and
Sanders-Brown Center on Aging,
Lexington, Kentucky, USA

Nobuhiko Ohno, MD, PhD
Postdoctoral Fellow,
Department of Neuroscience,
Lerner Research Institute,
Cleveland Clinic,
Cleveland, Ohio, USA

Daniel Ontaneda, MSc, MD
Staff Neurologist,
Mellen Center for Multiple Sclerosis,
Cleveland Clinic,
Cleveland, Ohio, USA

Harry T. Orr, PhD
Professor and Director,
Department of Laboratory Medicine and
Pathology and Institute for Translational Neuroscience,
University of Minnesota Medical School,
Minneapolis, Minnesota, USA

Amelie Pandraud, PhD
Professor of Neurology and Neurogenetics,
MRC Centre for Neuromuscular Diseases,
Department of Molecular Neuroscience,
UCL Institute of Neurology,
Queen Square, London, UK

Marc C. Patterson, MD, FRACP
Professor of Neurology, Pediatrics and Medical Genetics,
Departments of Neurology, Pediatrics and Medical Genetics,
Mayo Clinic Children’s Center,
Rochester, Minnesota, USA

Noah J. Pyles
Research Technician,
Department of Neurology,
Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA

Deborah L. Renaud, MD
Neurologist,
Departments of Neurology and Pediatrics,
Mayo Clinic,
Rochester, Minnesota, USA

Mark A. Ross, MD
Professor of Neurology,
Department of Neurology,
Mayo Clinic,
Scottsdale, Arizona, USA

Owen A. Ross, PhD
Associate Professor of Neuroscience,
Department of Neuroscience,
Department of Clinical Genomics,
Mayo Clinic, Jacksonville, Florida, USA

Anna Sailer, MD, PhD
Clinical Fellow,
Department of Neurology,
University Hospital Frankfurt, Frankfurt, Germany

Rodolfo Savica, MD
Assistant Professor of Neurology,
Department of Neurology,
Mayo Clinic Rochester, and
Mayo Clinic Alzheimer’s Disease Research Center,
Rochester, Minnesota, USA

Anthony H.V. Schapira, MD, DSc, FRCP, FMedSci
Professor, Institute of Neurology,
University College London,
London, UK

Lucia V. Schottlaender, MD
Research Fellow,
Department of Molecular Neuroscience,
UCL Institute of Neurology,
London, UK

Eric J. Sorenson, MD
Professor of Neurology,
Department of Neurology,
Mayo Clinic,
Rochester, Minnesota, USA

Charlotte J. Sumner, MD
Associate Professor of Neurology and Neuroscience,
Departments of Neurology and Neuroscience,
Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA

Sarah J. Tabrizi, BSc, MBChB, FRCP, PhD, FMedSci
Professor of Clinical Neurology and Consultant Neurologist,
Department of Neurodegenerative Disease,
UCL Institute of Neurology and National Hospital for
Neurology and Neurosurgery,
London, UK

Malcolm Taylor, PhD
Professor of Cancer Genetics, Interim Director,
Institute of Cancer and Genomic Sciences,
University of Birmingham, Edgbaston,
Birmingham, UK

Travis S. Tierney, MD, DPhil
Staff Neurosurgeon,
Division of Neurosurgery,
Nicklaus Children’s Hospital,
Miami, Florida, USA

Bruce D. Trapp, PhD
Chair and Professor,
Department of Neuroscience, Lerner Research Institute,
Cleveland Clinic,
Cleveland, Ohio, USA

Christian W....

Produkt-Details

• Erscheint lt. Verlag: 13.2.2017
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Schlagworte: ALS/MND • Alzheimer's • Anthony Schapira • Ataxias • Autoimmune neurodegeneration • Biowissenschaften • cerebellum • CJD • Cognitive Examinations • dementias • dementia with lewy bodies • Focal plaques • frontal lobe • Frontotemporal dementia • Huntington's • Life Sciences • Mechanisms of neurodegeneration • Medical Science • Medizin • Movement Examinations • MS • Myelin breakdown • Neurodegeneration • Neurodegenerative Erkrankung • Neurologie • Neurology • Neuroprotection • Neuroscience • Neurovascular Disease • Neurovaskuläre Krankheiten • Neurovaskuläre Krankheiten • Neurowissenschaften • Nicholas Wood • Non-focal plaques • Parkinson's • pharmacology • Plaque formation • prion disease • prion diseases • Ted M Dawson • Zbigniew Wszolek
• ISBN-10: 1-118-66191-5 / 1118661915
• ISBN-13: 978-1-118-66191-8 / 9781118661918