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Mathematical Modeling and Validation in Physiology

Applications to the Cardiovascular and Respiratory Systems

Jerry J. Batzel, Mostafa Bachar, Franz Kappel (Herausgeber)

Buch | Softcover

XX, 254 Seiten

2012
Springer Berlin (Verlag)
978-3-642-32881-7 (ISBN)

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This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data.Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.

1 Merging Mathematical and Physiological Knowledge: Dimensions and Challenges.- 2 Mathematical Modeling of Physiological Systems.- 3 Parameter Selection Methods in Inverse Problem Formulation.- 4 Application of the Unscented Kalman Filtering to Parameter Estimation.- 5 Integrative and Reductionist Approaches to Modeling of Control of Breathing.- 6 Parameter Identification in a Respiratory Control System Model with Delay.- 7 Experimental Studies of Respiration and Apnea.- 8 Model Validation and Control Issues in the Respiratory System.- 9 Experimental Studies of the Baroreflex.- 10 Development of Patient Specific Cardiovascular Models Predicting Dynamics in Response to Orthostatic Stress Challenges.- 11 Parameter Estimation of a Model for Baroreflex Control of Unstressed Volume.

Erscheint lt. Verlag	14.12.2012
Reihe/Serie	Lecture Notes in Mathematics
Reihe/Serie	Mathematical Biosciences Subseries
Zusatzinfo	XX, 254 p. 83 illus., 34 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	433 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Schlagworte	34-XX, 92-XX, 92C30, 92C42, 92C50, 93A30 • Experimental Design • interdisciplinary research • model development and parameter identification • Sensitivity Analysis
ISBN-10	3-642-32881-4 / 3642328814
ISBN-13	978-3-642-32881-7 / 9783642328817
Zustand	Neuware