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Stochastic Transport Processes in Discrete Biological Systems

Eckart Frehland (Autor)

Buch | Softcover

VIII, 174 Seiten

1982
Springer Berlin (Verlag)
9783540119647 (ISBN)

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These notes are in part based on a course for advanced students in the applications of stochastic processes held in 1978 at the University of Konstanz. These notes contain the results of re cent studies on the stochastic description of ion transport through biological membranes. In particular, they serve as an introduction to an unified theory of fluctuations in complex biological transport systems. We emphasize that the subject of this volume is not to introduce the mathematics of stochastic processes but to present a field of theoretical biophysics in which stochastic methods are important. In the last years the study of membrane noise has become an important method in biophysics. Valuable information on the ion transport mechanisms in membranes can be obtained from noise analysis. A number of different processes such as the opening and closing of ion channels have been shown to be sources of the measured current or voltage fluctuations. Bio logical 'transport systems can be complex. For example, the transport process can be coupled to other processes such as chemical reactions and take place in discontinuous structures of molecular dimensions. Furthermore, since there are strong electric fields or high concentration gradients across biological membranes ion transport processes of biological relevance are mostly processes far from equilibrium. For these reasons the development of new theoretical concepts has been necessary. The concept of transport in discrete systems has turned out to be more appropriate than continuum models.

A. Stochastic Processes.- 1. Expectation Values, Moments, Variance, Correlations.- 2. Probabilities.- 3. Binomial, Poisson, Normal Distributions.- 4. Stationarity and Ergodicity.- B. Analysis of Stationary Stochastic Processes.- 1. Basic Concepts of Noise Analysis.- 2. Poisson Processes, Carson's Theorem.- 3. The Master Equation Approach to Fluctuations.- C. Transport Fluctuations Around Steady States.- 1. Introductory Remarks on Transport Fluctuations.- 2. The Concept of Transport in Discrete Systems.- 3. Transport Fluctuations at Equilibrium.- 4. Theory of Transport Fluctuations Around Equilibrium and Nonequilibrium Steady States.- 5. Transport Fluctuations in Basic Membrane Transport Systems.- 6. Transport Fluctuations in More Sophisticated Channel Models.- 7. Invalidity of the Fluctuation-Dissipation Theorem for Transport Fluctuations Around Nonequilibrium Steady States.- 8. Current Noise: The Limit of High Applied Voltage.- D. Nonstationary Processes, Fluctuations at Transient States.- 1. A Simple Example: Identical, Independent Channels.- 2. Time-Dependent States in Markov Processes.- 3. Linear Birth-Death Processes With One Variable.- 4. Nonlinear Processes.- 5. Transport Noise at Transient States.- References.

Erscheint lt. Verlag	1.12.1982
Reihe/Serie	Lecture Notes in Biomathematics
Zusatzinfo	VIII, 174 p. 36 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	328 g
Themenwelt	Mathematik / Informatik ► Mathematik ► Algebra
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	binomial • Influence • Ionentransport • Stochastischer Prozess • Transport
ISBN-13	9783540119647 / 9783540119647
Zustand	Neuware