Coarse-Grained Modelling of DNA and DNA Self-Assembly (eBook)

Thomas E. Ouldridge (Autor)

eBook Download: PDF

2012 | 2012
XII, 176 Seiten
Springer Berlin (Verlag)
978-3-642-30517-7 (ISBN)

Infos

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

Inhalt

A Novel DNA Model.- Methods.- Finite Size Effects.- Structural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.

Produkt-Details

• Erscheint lt. Verlag: 9.7.2012
• Reihe/Serie: Springer Theses
• Reihe/Serie: Springer Theses
• Zusatzinfo: XII, 176 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik
• Themenwelt: Wirtschaft
• Schlagworte: Biological Motors • Coarse Grained Molecular Simulation • DNA nanotechnology • DNA Tweezers • DNA Walker • molecular self-assembly • Monte Carlo Algorithms
• ISBN-10: 3-642-30517-2 / 3642305172
• ISBN-13: 978-3-642-30517-7 / 9783642305177