Profiles of Drug Substances, Excipients and Related Methodology (eBook)

Critical Compilation of pKa Values for Pharmaceutical Substances

Harry G. Brittain (Herausgeber)

eBook Download: PDF

2007 | 1. Auflage
740 Seiten
Elsevier Science (Verlag)
978-0-08-055596-6 (ISBN)

Infos

Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic.

The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients, Analytical profiles of drug substances and excipients, Drug metabolism and pharmacokinetic profiles of drug substances and excipients, Methodology related to the characterization of drug substances and excipients, Methods of chemical synthesis, and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

* Presents comprehensive reviews covering all aspects of drug development and formulation of drugs
* Now encompassing critical review chapters
* Meets the information needs of the drug development community

Inhalt

Front Cover 1
Profiles of Driug Substances, Excipients, and Related Methodology 4
Copyright Page 5
Contents 6
Foreword 8
Acknowledgments 10
Dedication 12
Preface 14
Chapter 1: Critical Compilation of pKa Values for Pharmaceutical Substances 16
1. Introduction 16
1.1. The IUPAC pKa compilations 17
1.2. Limitations of current pharmaceuticals pKa compilations 19
2. Evaluation of Methods for pKa Determination 22
2.1. Inherent precision 22
2.2. Physicochemical factors controlling the accuracy and precision of pKa values 23
2.3. Validation of data quality 38
3. pKa Values from Computer Programs 39
4. Summary of the Data Compilation 41
References 43
Appendix A 50
Main List 50
pKa Values Found with Significant Data Quality Information—Mainly Primary Literature 50
Appendix B 440
Supplementary List-pKa Values Found with Little or No Data Quality Information—Mainly Secondary Literature 440
Index 642
Alphabetical Index of Drugs or Drug Related Compounds Found in pKa Database Files 642
Subject Index 740
Color Plate 1

Produkt-Details

• Erscheint lt. Verlag: 14.11.2007
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Themenwelt: Wirtschaft
• ISBN-10: 0-08-055596-9 / 0080555969
• ISBN-13: 978-0-08-055596-6 / 9780080555966