The 3R’s Approach in Preclinical Pharmacology

Promoting Animal Welfare and Scientific Ethics

Prashant Tiwari, K Sunil Kumar (Herausgeber)

Buch | Hardcover

582 Seiten

2025 | Unabridged edition
Cambridge Scholars Publishing (Verlag)
978-1-0364-4812-7 (ISBN)

Artikel merken

The 3R's (Replacement, Reduction, and Refinement) framework in preclinical pharmacology is fundamental for enhancing animal welfare and promoting ethical research. Replacement emphasizes the utilization of alternative approaches, such as in vitro systems or computational models, to reduce animal utilization. Reduction seeks to minimize the number of animals utilized by enhancing study designs and statistical techniques. Refinement improves animal welfare by optimizing experimental methods to mitigate pain, stress, and suffering. This ethical framework advocates for responsible scientific practices, guaranteeing that the utilization of animals is warranted and executed with the utmost standards of welfare and rigor. It examines how these ethical principles contribute to reducing animal usage, refining study designs, and improving animal welfare while maintaining scientific integrity. This book offers a framework for researchers dedicated to integrating scientific advancement with ethical accountability by adopting new approaches, optimizing experimental techniques, and enhancing animal welfare. Crucial literature for scientists, ethicists, and politicians, it emphasizes the significance of humane practices in the progression of biomedical research.

Dr Prashant Tiwari, PhD, is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He holds a PhD from Siksha O Anusandhan University, Bhubaneswar, India, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi, India. With over 13 years of experience in teaching and research, Dr Tiwari's expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. Dr K. Sunil Kumar is a Professor at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India, with 16 years of teaching experience. His research interests encompass neuropharmacology, metabolic disorders, organ-protective activities, and drug interactions. He holds a PhD in Pharmaceutical Sciences from Jawaharlal Nehru Technological University Hyderabad, India, and has authored 65 research and review articles. In addition to publishing 5 books and 4 book chapters, he holds 6 patents.

Erscheinungsdatum	03.06.2025
Verlagsort	Newcastle upon Tyne
Sprache	englisch
Maße	148 x 212 mm
Themenwelt	Naturwissenschaften ► Biologie ► Zoologie
	Sozialwissenschaften ► Soziologie
	Veterinärmedizin ► Allgemein ► Alternative Heilverfahren
ISBN-10	1-0364-4812-6 / 1036448126
ISBN-13	978-1-0364-4812-7 / 9781036448127
Zustand	Neuware