Pharmaceutical Powder Compaction Technology

Buch | Hardcover

344 Seiten

2011 | 2nd edition
Crc Press Inc (Verlag)
978-1-4200-8917-2 (ISBN)

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Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.

This unique reference covers:

The physical structure of pharmaceutical compacts
Bonding phenomena that occur during powder compaction
Compression mechanisms of pharmaceutical particles
Theories and basic principles of powder compaction

New topics include:

Compaction data analysis techniques
The migration of powder constituents into commercial manufacture
Instrumentation for compaction
Compaction functionality testing, which is likely to become a USP requirement
Design space for compaction
Metrics required for scalability in tablet compression
Interactive compaction and preformulation database for commonly used excipients

Metin Çelik

Theory of Compaction: Intermolecular Bonding Forces: where materials and process come together. Compaction Data Analysis Techniques: Viscoelastic Models. Application of Percolation Theory and Fractal Geometry to Tablet Compaction. Post Compaction Data Analysis TechniquesIntrumentation and Equipment in Compaction: Tablet Press Instrumentation in the Research and Development Environment. Advanced Compaction Research Equipment: Compaction Simulators. Compactability Functionality Test. Role of Compaction in the Formulation and Process Development of Tabletting: Compaction Properties of Directly Compressible Materials. Lubrication Issues in Direct Compaction. Crystal Engineering and Particle Design for the Powder Compaction Process. Compaction of Combination Products. Quality by Design and Compression . Expert Systems and Their Use in Pharmaceutical Applications. Press-To-Press Scalability and Transitioning Factors.

Erscheint lt. Verlag	22.8.2011
Reihe/Serie	Drugs and the Pharmaceutical Sciences
Zusatzinfo	165 Line drawings, black and white; 41 Halftones, black and white; 205 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	178 x 254 mm
Gewicht	876 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
Themenwelt	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	1-4200-8917-X / 142008917X
ISBN-13	978-1-4200-8917-2 / 9781420089172
Zustand	Neuware