Identification of lung-physiological parameters with dynamic positron-emission tomography and tracer kinetic modeling
Seiten
2007
TUDpress Verlag der Wissenschaften Dresden
978-3-940046-46-8 (ISBN)
TUDpress Verlag der Wissenschaften Dresden
978-3-940046-46-8 (ISBN)
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Lung function is vital to the organism. There is a multitude of acute
and chronic diseases where this function can be impaired, and understanding and identifying the mechanisms of lung injury is key to clinical management of this life-threatening condition. To provide the technological means of elucidating some of these mechanisms, this book formally derives and discusses a coherent strategy for system identification with dynamic positron-emission tomography (PET) imaging of the radiotracer [18F]-labeled 2-fluoro-2-deoxyglucose (18F-FDG). This strategy comprises methods of image processing to obtain time-activity curves from dynamic PET data, of continuous time least-squares parameter identification, and analytical methods of model validation. Furthermore, a non-invasive, model-based method of acquiring a pulmonary 18F-FDG input function is being developed. Pulmonary PET imaging data from settings of acute lung injury due to smoke inhalation and mechanical ventilation are analyzed.
and chronic diseases where this function can be impaired, and understanding and identifying the mechanisms of lung injury is key to clinical management of this life-threatening condition. To provide the technological means of elucidating some of these mechanisms, this book formally derives and discusses a coherent strategy for system identification with dynamic positron-emission tomography (PET) imaging of the radiotracer [18F]-labeled 2-fluoro-2-deoxyglucose (18F-FDG). This strategy comprises methods of image processing to obtain time-activity curves from dynamic PET data, of continuous time least-squares parameter identification, and analytical methods of model validation. Furthermore, a non-invasive, model-based method of acquiring a pulmonary 18F-FDG input function is being developed. Pulmonary PET imaging data from settings of acute lung injury due to smoke inhalation and mechanical ventilation are analyzed.
| Reihe/Serie | Dresdner Beiträge zur Medizintechnik ; 4 |
|---|---|
| Zusatzinfo | zahlr. z.T. farb. Abb. |
| Sprache | englisch |
| Maße | 148 x 210 mm |
| Einbandart | kartoniert |
| Themenwelt | Technik ► Elektrotechnik / Energietechnik |
| ISBN-10 | 3-940046-46-9 / 3940046469 |
| ISBN-13 | 978-3-940046-46-8 / 9783940046468 |
| Zustand | Neuware |
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