Extracellular Mitochondria in Health and Disease

Carla Lopes, Paulo César da Silva Pinheiro (Herausgeber)

Buch | Softcover

198 Seiten

2025
Academic Press Inc (Verlag)
978-0-443-29283-5 (ISBN)

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Extracellular Mitochondria in Health and Disease covers this new and significant area of research, shedding light on their roles in intercellular communication and disease pathology. These tiny powerhouses, traditionally known for their intracellular functions, are now recognized for their extracellular activities that impact various physiological and pathological processes. The book delves into a range of topics, including cellular mechanisms of mitochondrial transfer, metabolic signaling, and the crosstalk between extracellular vesicles and mitochondria. It serves as a comprehensive guide for scientists, researchers, and students eager to explore these novel findings and their potential implications.

Other sections examine the roles of extracellular mitochondria in immune regulation and inflammation, neurodegeneration and neuroprotection, and their therapeutic potential. By bridging gaps in existing literature, this resource offers up-to-date research and discoveries, providing valuable insights into how extracellular mitochondria could revolutionize medical advancements and improve patient outcomes.

Dr. Carla Lopes graduated in Biomedical Engineering in 2010. Her Ph.D. was focused on modeling neurodegenerative diseases first by using transgenic mouse models and later patient-derived induced pluripotent stem cells (iPSC) to understand metabolic and mitochondrial abnormalities. In 2015, she worked as a Post Doc supported by a grant from a project financed by The Luso-American Development Foundation Life Science 2020 at the Center for Neuroscience and Cell Biology. In this project, she worked mainly on metabolic and mitochondrial abnormalities in fibroblasts, iPSC and neural stem cells obtained from late-onset HD and genetically corrected counterparts. In 2018, Dr. Lopes received a grant funded by FCT as a Principal Investigator "iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics". In 2023 she was hired as an Assistant researcher at the Multidisciplinary Institute of Ageing, Coimbra. Dr. Paulo Pinheiro graduated in Applied Biology in 2001. His PhD was focused on characterizing the function/pharmacology of presynaptic glutamate receptors and their contribution to brain disorders. In 2009 he moved to the Institute for Neuroscience and Pharmacology, Copenhagen, where he obtained, among others, a prestigious 2-year Marie Curie Intra-European Fellowship and a large grant from the pharma industry. Here, his work was devoted to studying vesicle biogenesis, the vesicle priming process and the molecular mechanisms of neurotransmitter release. In 2012 Paulo won a competitive 5-year FCT investigator position at the CNC, Portugal, which he effectively took in 2015. He is currently part of the large Synapse Biology group led by Ana Luísa Carvalho, with a fully equipped electrophysiology lab, Coimbra, and collaborates extensively in-house and with international colleagues in diverse research topics. In 2023 he was hired in a tenure track position as Assistant Professor at the Department of Life sciences, University of Coimbra.

Chapter 1. General introduction
Marvin Edeas
Chapter 2. Cellular mechanisms of mitochondrial transfer and metabolic
signaling
Beatriz Guedes, Inês Melo-Marques, Ana Raquel Esteves and Sandra Morais Cardoso
Chapter 3. Modern techniques for studying extracellular mitochondria
Pasquale D'Acunzo, Efrat Levy and Carla Lopes
Chapter 4. Interplay between extracellular vesicles and mitochondria
Patricia Coelho and Paulo Pinheiro
Chapter 5. Extracellular mitochondria: dual roles in neurodegeneration and neuroprotection
Tomas Ferro, Adrián Tejero and Filipe Duarte
Chapter 6. Extracellular vesicles bearing mitochondria in cardiometabolic diseases
M. Carmen Martinez and Ramaroson Andriantsitohaina Ramaroson
Chapter 7. Therapeutic potential of extracellular mitochondria: applications and challenges
Cristina Mas-Bargues, Javier Huete-Acevedo, Marta Arnal-Forné, Sandra Atencia-Rabadán, José de Santiago-Montesinos, Karolina Dorosz and Consuelo Borrás
Chapter 8. Conclusions and future perspectives
Carla Lopes

Erscheinungsdatum	04.11.2025
Reihe/Serie	Translational and Applied Bioenergetics
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	450 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Naturwissenschaften ► Biologie ► Biochemie
	Technik ► Medizintechnik
ISBN-10	0-443-29283-3 / 0443292833
ISBN-13	978-0-443-29283-5 / 9780443292835
Zustand	Neuware