Comprehensive Chemistry and Biology of Coumarins Scaffold

Shehryar Hameed, Khalid Mohammed Khan, Mehwish Solangi (Autoren)

Buch | Softcover

400 Seiten

2026
Elsevier - Health Sciences Division (Verlag)
978-0-443-15650-2 (ISBN)

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Comprehensive Chemistry and Biology of Coumarins Scaffold covers detailed methods and protocols to synthetize Coumarin derivatives and different applications and future perspectives for these compounds. Coumarin-Based Scaffolds plays an important role in organic, bioorganic, and medicinal chemistry as they act as a bridge between chemistry, life sciences, and biochemical investigations. Coumarin is an important scaffold for designing, generating a wide variety of chemical libraries and drug-like candidates to obtain desired therapeutic and pharmacological properties. Specific functional groups are covered as well as the synthesis of bioactive compounds against specific pathological conditions.

The discovery of new coumarin-based drug candidates during the last decades has been covered to assist the pharmaceutical, bioorganic and medicinal chemists for their further research on coumarin-based molecules.

Shehryar Hameed obtained his M.Phil. degree in Organic Chemistry from H.E.J Research Institute of Chemistry, the University of Karachi under the supervision of Prof. Dr. Khalid. M. Khan. He is currently a doctoral researcher at the H.E.J Research Institute of Chemistry, University of Karachi. His research is focused on the “Synthesis of Some Biologically Active Compounds and Developing New Synthetic Methodologies. His research interests are the synthesis of versatile scaffolds such as substituted quinoxaline, 1,2,3-triazole, phenyl-3,4-dihydropyrimidin-2(1H)-one and pyran heterocyclic derivatives in search of potential therapeutic agents and their broad range of medicinal applications for the development of novel α-amylase, α-glucosidase, urease, and cholinesterase inhibitors. He has numerous publications to his credit in various reputed journals of high impact factor. Prof. Dr. Khan is among the most prominent scientists of Pakistan recognized for his original contributions in the field of medicinal chemistry and drug discovery. He established a world-class medicinal and synthetic laboratory at the International Center for Chemical and Biological Sciences, University of Karachi, focusing on the discovery of new enzyme inhibitors and other bioactive compounds. He is mentoring a large number of young researchers in the field of drug designing and drug and designing. He enriched world literature with several novel classes of bioactive substances and helped in the development of new pharmacophores. The major emphasis of his work is on the synthesis of inhibitors of clinically important enzymes. In his work, he uses a minimum pharmacophore approach and concentrates on the understanding of the functional profile of the active parts of potential drug candidates. His current research interests also include bioassay-directed isolation of natural products and the development of nano-medicines. Mehwish Solangi has obtained her M.Phil. degree in Organic Chemistry from H.E.J. Research Institute of Chemistry, the University of Karachi under the supervision of Prof. Dr. Khalid. M. Khan. Currently, she is a doctoral researcher at the H.E.J. Research Institute of Chemistry, University of Karachi. Her research was then focused on the “Synthesis and Bioactivities of Indole and Indoline Derivatives. Her present research interests involve the synthesis of versatile scaffolds based on substituted Indole, Benzisoxazole, and pyridazine heterocyclic derivatives in search of potential therapeutic agents and their broad range of medicinal applications for the development of novel drug candidates against antidiabetic, anti-Alzheimer’s, ROS scavengers.

1. General introduction of coumarin
2. Synthesis and reactivity
3. Naturally occurring coumarins in the development of commercial drugs
4. Multi-targeted scaffold in medicinal chemistry: Potential anticancer agents
5. Role of coumarins in different infectious diseases
6. In the design and development of neurotherapeutics agents
7. Development as anti-inflammatory and anticoagulant agents
8. Potential in antidiabetic and antioxidant therapies
9. Coumarin-based metal complexes and polymers
10. Recent advances in applications of coumarins: A brief discussion on patents and activities, current status and perspectives

Erscheint lt. Verlag	13.2.2026
Verlagsort	Philadelphia
Sprache	englisch
Maße	152 x 229 mm
Gewicht	450 g
Themenwelt	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-443-15650-6 / 0443156506
ISBN-13	978-0-443-15650-2 / 9780443156502
Zustand	Neuware