Synthetic Nucleic Acids as Inhibitors of Gene Expression

Mechanisms, Applications, and Therapeutic Implications

Buch | Hardcover

204 Seiten

2004
Crc Press Inc (Verlag)
978-0-8493-3025-4 (ISBN)

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Presents the research on inhibitors of gene expression and nucleic acid-based drugs. This book features numerous charts, diagrams, and graphs. It covers the subject from lab bench to cancer-related clinical trials. It describes mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys.

In the post-genomic era we have, at our fingertips, an incredible array of genomic sequences from a multitude of complex organisms. There remains, however, the critical need to understand the precise roles individual genes play in complex biological milieu. Bringing together authoritative reviews by renowned international leaders, this book presents cutting-edge research on inhibitors of gene expression and nucleic acid-based drugs. With numerous charts, diagrams, and graphs, the book covers the subject from lab bench to cancer-related clinical trials, making it an up-to-date and critical resource. Coverage includes discussions of ribozyme subtypes, structure-function aspects, and therapeutic applications; DNAzymes, their various subtypes, kinetics and biochemistry, and applications in target validation. Lastly, the mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys are described.

Levon Michael Khachigian

Foreword. Therapeutic Application of Ribozymes for Cardiovascular Disease. Development of Ribozymes as Cancer Therapeutics. RNA Interference: A Technology Based on an Ancient Gene Silencing Pathway. RNA-Cleaving DNA Enzymes in Gene Silencing: Room for Improvement? Deoxyribozymes and Medical Innovation. Effect of Modifications on the Intracellular Activity of a DNA Enzyme. Potential Therapeutic Applications of DNA Enzymes and siRNAs Against Viral and Cellular Genes. Use of DNAzymes for Target Gene Validation. DNAzymes Targeting Immediate-Early Genes as Inhibitors of Angiogenesis and Restenosis. Decoy Oligodeoxynucleotides as Viable Pharmaceutical Drugs.

Erscheint lt. Verlag	29.11.2004
Zusatzinfo	7 Tables, black and white; 46 Halftones, black and white; 46 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	408 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-8493-3025-4 / 0849330254
ISBN-13	978-0-8493-3025-4 / 9780849330254
Zustand	Neuware