Development of In-Tether Carbon Chiral Center-Induced Helical Peptide

Methodology and Applications

Kuan Hu (Autor)

Buch | Hardcover

102 Seiten

2021 | 2021 ed.
Springer Verlag, Singapore
9789813366121 (ISBN)

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This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.

Introduction.- Method to construct in-tether chiral center constrained helical peptide.- Application in disrupting p53/MDM2 protein-protein interactions.- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.

Erscheinungsdatum	29.01.2021
Reihe/Serie	Springer Theses
Zusatzinfo	65 Illustrations, color; 10 Illustrations, black and white; XV, 102 p. 75 illus., 65 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Technik ► Maschinenbau
Schlagworte	Cell permeability • chirality • Helicity • protein-protein interactions • Self-Assembly • Stabilized peptide • Staple peptide
ISBN-13	9789813366121 / 9789813366121
Zustand	Neuware