Hippocampal Microcircuits (eBook)

A Computational Modeler's Resource Book

Vassilis Cutsuridis, Bruce P. Graham, Stuart Cobb, Imre Vida (Herausgeber)

eBook Download: PDF

2019 | 2nd ed. 2018
XVII, 885 Seiten
Springer International Publishing (Verlag)
978-3-319-99103-0 (ISBN)

Infos

This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus. 

The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them.     

This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information.

Inhalt

PrefacePart I Experimental Background
Connectivity of the Hippocampus
Morphology of Hippocampal Neurons
Physiological properties of hippocampal neurons
Glutamatergic Neurotransmission in the Hippocampus
Fast and slow GABAergic transmission in hippocampal circuits
Synaptic plasticity at hippocampal synapses – experimental background
Neuromodulation of hippocampal cells and circuits
Cell Type-Specific Activity during Hippocampal Network Oscillations in Vitro
Recording identified neurons in awake and anesthetized rodents
Spatial, temporal, and behavioral correlates of hippocampal neuronal activity: A primer for computational analysis
Part II Computational Analysis
Systematic Data Mining of Hippocampal Synaptic Properties
Spatio-Temporal Patterns of Granule Cell Activity Revealed by a Large-Scale, Biologically Realistic Model of the Hippocampal Dentate Gyrus
A model of spatial reach in LFP recordings
Models of Rate and Phase Coding of Place Cells in Hippocampal Microcircuits
A model for grid firing and theta-nested gamma oscillations in layer 2 of the medial entorhinal cortex
Computational Models of Grid Cell Firing
Modeling synaptic plasticity in hippocampus: a calcium-based approach
Simplified Compartmental Models of CA1 Pyramidal Cells of Theta-Modulated Inhibition Effects on Spike Timing-Dependent Plasticity
Factors affecting STDP in the dendrites of CA1 pyramidal cells
Computational examination of synaptic plasticity and metaplasticity in hippocampal dentate granule neurons
Genome-wide associations of schizophrenia studied with computer simulation
MODELLING EPILEPTIC ACTIVITY IN HIPPOCAMPAL CA3
A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus
Resources for Modeling in Computational Neuroscience
Experiment-modelling cycling with populations  of  multi-compartment  models: application  to  hippocampal  interneurons Index
 

Produkt-Details

• Erscheint lt. Verlag: 4.2.2019
• Reihe/Serie: Springer Series in Computational Neuroscience
• Zusatzinfo: XVII, 879 p. 182 illus., 120 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Technik
• Schlagworte: anatomy • Behavior • Computational Neuroscience • Cortex • declarative memories • hippocampus • Microcircuits • neurons • Physiology • Radiologieinformationssystem • synaptic properties
• ISBN-10: 3-319-99103-5 / 3319991035
• ISBN-13: 978-3-319-99103-0 / 9783319991030