Active Pharmaceutical Ingredients in Synthesis (eBook)

Catalytic Processes in Research and Development

Anthony J. Burke, Carolina Silva Marques, Nicholas J. Turner, Gesine J. Hermann (Autoren)

eBook Download: EPUB

2018
Wiley-VCH Verlag GmbH & Co. KGaA
9783527807260 (ISBN)

Infos

Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods

This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis.

Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis.

-Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production
-Focuses on the application of catalytic methods for the synthesis of known APIs
-Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more
-Includes recent patent literature for completeness

Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.

Autor

Anthony J. Burke, PhD, is Professor at the University of Evora, and the coordinator of the organic and organometallic research line at the Centro de Química de Evora. Carolina S. Marques, PhD, is working as a PostDoc in the Burke group. Nicholas Turner, PhD, is Professor of Chemical Biology, Director of the Centre of Excellence in Biocatalysis (CoEBio3) and co-Director of SYNBIOCHEM. Gesine J. Hermann, PhD, is a research and business consultant for ChiraTecnics, Portugal.

Inhalt

Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape
Catalytic Process Design - The Industrial Perspective
Hydrogenation, Hydroformylation and Other Reductions
Oxidation: Nobel Prize Chemistry Catalysis
Catalytic Addition Reactions
Catalytic Cross-Coupling Reactions - Nobel Prize Catalysis
Catalytic Metathesis Reactions - Nobel Prize Catalysis
Catalytic Cycloaddition Reactions: Coming Full-Circle
Catalytic Cyclopropanation Reactions
Catalytic C-H insertion Reactions
Phase Transfer Catalysis
Biocatalysis: Nobel Prize Catalysis

Produkt-Details

• Erscheint lt. Verlag: 17.10.2018
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• Schlagworte: Active pharmaceutical ingredient (API) • asymmetric catalytic reactions • Biocatalysis • Catalysis & Chemical Reaction Engineering • catalyst processes • catalytic chemistry • catalytic organic synthesis • catalytic processes for drugs • Catalytic Reactions • chemical engineering • chemical ingredients in pharmaceuticals • chemical processing • Chemical Synthesis • Chemie • Chemische Synthese • Chemische Verfahrenstechnik • Chemistry • CH Insertions • Diels-Alder • drug process intensification • drug sustainability • drug synthesis • drug waste reduction • Katalyse • Katalyse u. Chemische Reaktionstechnik • <i>Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development</i></p> • <p>pharmaceuticals • medicinal chemistry • Metal-catalytic coupling-reactions • Methods - Synthesis & Techniques • Organische Chemie / Methoden, Synthesen, Verfahren • Organometallics • Pharmaceutical & Medicinal Chemistry • Pharmaceutical Chemistry • pharmaceutical ingredients • pharmaceutical synthesis • Pharmaceutics • Pharmazeutische Chemie • Pharmazeutische u. Medizinische Chemie • synthesis of chiral amines • Synthetic biology • Synthetic chemistry • the chemical industry
• ISBN-13: 9783527807260 / 9783527807260