Pharmacokinetics in Drug Discovery and Development

Buch | Hardcover

440 Seiten

2002
Crc Press Inc (Verlag)
978-1-56676-973-0 (ISBN)

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From basic principles to industrial and regulatory applications to clinical and research applications, this book reviews the subspecialties in the field of pharmacokinetics. It covers topics such as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, and linear systems approaches.

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference.

After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

Ronald D. Schoenwald

BASIC PRINCIPLES: Basic Principles. INDUSTRIAL AND REGULATORY APPLICATIONS: PK/PD Approach. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development. Phase I, II, and III FDA Submissions. Bioavailability and Bioequivalence. CLINICAL APPLICATIONS: General Approaches to Clinical Pharmacokinetic Monitoring. Aminoglycosides and Other Antibiotics. Cardiovascular Agents. Psychotropic Agents. Theophylline. Anticonvulsant Agents. RESEARCH APPLICATIONS: Classical Modeling. Non-compartmental Modeling. Physiologically-Based Pharmacokinetic Models. Population Pharmacokinetics. The Linear Systems Approach.

Zusatzinfo	3 Halftones, black and white; 50 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	970 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Technik
ISBN-10	1-56676-973-6 / 1566769736
ISBN-13	978-1-56676-973-0 / 9781566769730
Zustand	Neuware