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Chiral Recognition and Separation Mechanisms

Nelu Grinberg, Nizar Haddad, Shengli Ma (Autoren)

Buch | Hardcover

350 Seiten

2025
Crc Press Inc (Verlag)
978-1-4398-5257-6 (ISBN)

Noch nicht erschienen (ca. Mai 2025)
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Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

Nelu Grinberg is with Boehringer Ingelheim Pharmaceuticals, in Connecticut, USA.

Introduction. Symmetry. Separation of Enantiomers through the Formation of Diastereomers. Non-chromatographic Methods for the Determination of Enantiomeric Excess. Mechanism of Chromatographic Chiral Discrimination & Thermodynamics of Chromatographic Chiral Discrimination. Chiral Separation with Taylor Made Polymers. Chiral Separation through Ligand Exchange. Chiral Separation through H-bonds. Chiral Separation through Charge Transfer. Chiral Separation through Inclusion Compounds. Protein Phases and Antibiotic Phases. Polysaccharide Phases. Separation of Enantiomers with Chiral Mobile Phases. Strategies for Method Development for Chiral Separation. Conclusion/Summary and Future Possibilities.

Erscheint lt. Verlag	15.5.2025
Reihe/Serie	Chromatographic Science Series
Zusatzinfo	70 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	152 x 229 mm
Gewicht	453 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Chemie ► Analytische Chemie
	Technik
ISBN-10	1-4398-5257-X / 143985257X
ISBN-13	978-1-4398-5257-6 / 9781439852576
Zustand	Neuware