Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface Modification
Seiten
2016
Springer Berlin (Verlag)
978-3-662-53397-0 (ISBN)
Springer Berlin (Verlag)
978-3-662-53397-0 (ISBN)
This thesis focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of "affinity guided covalent conjugation." This newly established methodology provides complementary resolution to protein labeling, imaging and trafficking. By systematically investigating the coordination interaction between protein and quantum dots using various engineered protein ligands, this thesis proposes a general rule for protein self-assembly on the surface of quantum dots and reports a revolutionized nanobelt protein in accordance with this rule. It is an extraordinary example of interdisciplinary research, providing answers to real-life biological problems from a chemistry perspective.
Introduction.- Biological Active Antifungal Peptides.- Protein Ligands Engineering.- Coiled Coil Binding Induced Covalent Cross-linking.- Cell Surface Receptor Labeling.- Summary and Conclusion.
| Erscheinungsdatum | 15.10.2016 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XIII, 96 p. 46 illus., 41 illus. in color. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | Antifungal peptides • biochemistry • bioorganic chemistry • Biotechnology • Cell labeling • Chemistry and Materials Science • Coiled-coil interaction • Covalent protein conjugation • nanotechnology • Peptide tag • Protein Folding • Protein ligands engineering • Protein-nanoparticle assemblies • Protein-peptide interactions • Protein Science • Protein self-assembly |
| ISBN-10 | 3-662-53397-9 / 3662533979 |
| ISBN-13 | 978-3-662-53397-0 / 9783662533970 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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