Manipulation of Multiphase Materials for Touch-less Nanobiotechnology (eBook)

A Pyrofluidic Platform

Sara Coppola (Autor)

eBook Download: PDF

2016 | 1st ed. 2016
XV, 109 Seiten
Springer International Publishing (Verlag)
978-3-319-31059-6 (ISBN)

Infos

The thesis presents an original and smart way to manipulate liquid and polymeric materials using a 'pyro-fluidic platform' which exploits the pyro-electric effect activated onto a ferroelectric crystal. It describes a great variety of functionalities of the pyro-electrohydrodynamic platform, such as droplet self-assembling and dispensing, for manipulating multiphase liquids at the micro- and nanoscale. The thesis demonstrates the feasibility of non-contact self-assembling of liquids in plane (1D) using a micro engineered crystal, improving the dispensing capability and the smart transfer of material between two different planes (2D) and controlling and fabricating three-dimensional structures (3D).

The thesis present the fabrication of highly integrated and automated 'lab-on-a-chip' systems based on microfluidics. The pyro-platform presented herein offers the great advantage of enabling the actuation of liquids in contact with a polar dielectric crystal through an electrode-less configuration. The simplicity and flexibility of the method for fabricating 3D polymer microstructures shows the great potential of the pyro-platform functionalities, exploitable in many fields, from optics to biosensing. In particular, this thesis reports the fabrication of optically active elements, such as nanodroplets, microlenses and microstructures, which have many potential applications in photonics.

The capability for manipulating the samples of interest in a touch-less modality is very attractive for biological and chemical assays. Besides controlling cell growth and fate, smart micro-elements could deliver optical stimuli from and to cells monitoring their growth in real time, opening interesting perspectives for the realization of optically active scaffolds made of nanoengineered functional elements, thus paving the way to fascinating Optogenesis Studies.

Inhalt

Publications Related to This Thesis 6
Supervisor’s Foreword 9
Acknowledgments 11
Contents 12
About the Author 14
1 Introduction 15
2 Pyro-Electric Effect and Polymers Self-assembling 19
2.1 Wettability Patterning by Pyroelectric Effect 19
2.2 The Pyro-Electric Effect onto a PPLN Crystal 22
2.3 Manipulation of Polymer Materials for Patterning Micro Lenses 24
2.4 Manipulating Liquid Crystal Droplets onto Polymer Microlenses 28
References 35
3 Pyro-Electrohydrodynamic Printing and Multi Jets Dispenser 37
3.1 Looking Through High Resolution Printing 37
3.2 Pyro-Electrohydrodynamic Dispenser: Set-up 38
3.3 Functionalities of the Pyro-Electrohydrodynamic Dispenser 41
3.4 Laser Induced Dispenser and Visualization of the Pyro-Electric Field Lines 44
3.5 Laser Induced Dispenser Activated by Plasmon Resonace of Gold Nanorods 46
3.6 Dispenser for Liquid Printing and Patterning at High Resolution 50
3.7 Multi Jets for the Pyro-EHD Dispenser 54
3.8 Pyro-EHD Process and Instability of Liquid Film 56
3.9 Polymer Multi Jetting 56
3.10 Liquid Delivering 58
3.11 Fabrication of Optical Microlenses Through the Pyro-Dispenser 59
References 67
4 Pyro-EHD Lithography, Fabrication and Employment of 3D Microstructures 69
4.1 Controlling Liquid Instabilities for Fabrication of Polymer 3D Microstructures 69
4.2 Design and Working Principle of the Technique 70
4.3 Experimental Procedure of Fabrication by Pyro-EHD 71
4.4 High Aspect Ratio Micron-Sized Structures Formation 73
4.5 Applications of Rapid Cured PDMS Microstructures 76
4.5.1 Micro-Axicons as Optical Tweezers by Bessel Beams 76
4.5.2 Whispering Gallery Mode (WGM) Microresonators 81
4.5.3 TeraHz Tuning of Whispering Gallery Modes in a PDMS Microsphere 83
References 85
5 High Resolution Patterning of Biomaterials for Tissue Engineering 87
5.1 Introduction to the High Precision Patterning by Pyro-EHD 87
5.2 Experimental Set-up and Pyro-Electric Spinning Characterization 89
5.3 Fabrication of Well-Ordered Biocompatible and Biodegradable Patterns 92
5.4 Cell Contact Guidance onto Ordered Fibers 95
References 97
6 Biodegradable Microneedles for Transdermal Drug Delivery 99
6.1 Biodegradable Microneedles and Conventional Production Technologies 99
6.2 Pyro-Electric Fabrication of Dissolving Microneedles 101
6.3 Skin Indentation by PLGA Electro-Drawn Microneedles 108
References 110
7 Conclusion and Perspectives 112
Appendix A 115
Appendix BCharacterization of the Pyro-EHDDispenser for Different Liquids 119

Produkt-Details

• Erscheint lt. Verlag: 3.4.2016
• Reihe/Serie: Springer Theses
• Reihe/Serie: Springer Theses
• Zusatzinfo: XV, 109 p. 86 illus., 76 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: 3D lithography • Drug delivery through microneedles • lab-on-a-chip • Liquids self-assembly • Polymer micro lenses • Pyro-electric effect
• ISBN-10: 3-319-31059-3 / 3319310593
• ISBN-13: 978-3-319-31059-6 / 9783319310596