Applications of Toxicogenomics in Safety Evaluation and Risk Assessment (eBook)

Darrell R. Boverhof, B. Bhaskar Gollapudi (Herausgeber)

eBook Download: EPUB | PDF

2011
John Wiley & Sons (Verlag)
978-1-118-00103-5 (ISBN)

Infos

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences.

B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.

Inhalt

PREFACE ix

CONTRIBUTORS xi

1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER
1

Darrell R. Boverhof and B. Bhaskar Gollapudi

2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13

Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and
Lynne T. Haber

3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS
TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH
FORWARD 41

Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and
Heli Hollnagel

4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF
TOXICOGENOMICS DATA 65

Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger
Perkins, and Leming Shi

5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN
CARCINOGENESIS 81

Jiri Aubrecht and Ebru Caba

6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE
MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99

Mark R. Fielden

7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117

Jorge M. Naciff and George P. Daston

8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION
PROFILING 147

M. Ann Mongan and Hisham K. Hamadeh

9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177

Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T.
Smith

10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT
207

Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T.
Ankley

11 ANALYSIS OF TRANSCRIPTOMIC DOSE-RESPONSE DATA FOR
TOXICOLOGY AND RISK ASSESSMENT 237

Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin
E. Andersen

12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN
EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS,
AND CHALLENGES 251

Alan Dombkowski and J. Craig Rowlands

13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267

Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S.
Kleinjans

14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293

Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y.
Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston,
Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H.
Benson

15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY
EVALUATION: ACTIVITIES IN JAPAN 323

Ken-ichi Aisaki and Jun Kanno

16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION
331

Lois D. Lehman-McKeeman and William R. Foster

17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS
BIOLOGY APPROACH 349

Sarah N. Campion and Kim Boekelheide

INDEX 357

Produkt-Details

• Erscheint lt. Verlag: 11.10.2011
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Arbeitssicherheit u. Umweltschutz i. d. Chemie • Biowissenschaften • Chemical and Environmental Health and Safety • Chemie • Chemistry • Genomforschung u. Proteomik • Genomics & Proteomics • Life Sciences • toxicogenomics, toxicogenomics book, toxicogenomics guide, applications of toxicogenomics, toxicogenomics and risk assessment, toxicogenomics in safety evaluation, mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, ecotoxicology • Toxicology • Toxikologie
• ISBN-10: 1-118-00103-6 / 1118001036
• ISBN-13: 978-1-118-00103-5 / 9781118001035