Solid State Characterization of Pharmaceuticals (eBook)

Richard A. Storey, Ingvar Ymén (Herausgeber)

eBook Download: PDF

2011
John Wiley & Sons (Verlag)
978-0-470-65935-9 (ISBN)

Infos

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.

This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. 

The following topics are included:    

• Physical properties and processes
• Thermodynamics
• Intellectual  guidance
• X-ray diffraction
• Spectroscopy Microscopy
• Particle sizing
• Mechanical properties
• Vapour sorption
• Thermal analysis & Calorimetry
• Polymorph prediction
• Form selection

Richard A. Storey, AstraZeneca Pharmaceuticals, Macclesfield, UK

Ingvar Ymén, AstraZeneca R&D, Södertälje, Sweden

Inhalt

1. Introduction to the Solid State - Physical Properties and Processes - Ingvar Ym´en
2. X-Ray Diffraction - C. J. Gilmore
3. Spectroscopic Characterization - Andrew O'Neil and Howell Edwards
4. Thermal Analysis - Conventional Techniques - Mark Saunders and Paul Gabbott
5. Thermal Analysis - Dielectric Techniques - Susan Barker and Milan D. Antonijevic
6. Isothermal Calorimetric Analysis - Andrew Hills
7. Calorimetric Methods - Solution Calorimetry - Simon Gaisford
8. Vapour Sorption and Surface Analysis - Jerry Y. Y. Heng and Daryl R. Williams
9. Microscopy - Gary Nichols
10. Particulate Analysis - Mechanical Properties - R. J. Roberts
11. Particulate Analysis - Particle Size - Xian-Ming Zeng
12. Computational Polymorph Prediction - Sarah L. Price and Louise S. Price
13. Patenting of Inventions Relating to Polymorphs - Bertrand Gellie, Claire Johnson and Thomas Weisbrod
14. A 'Roadmap' to Solid Form Selection - Richard Storey

Produkt-Details

• Erscheint lt. Verlag: 31.3.2011
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Themenwelt: Technik
• Schlagworte: Ability • Analytical Chemistry • Analytische Chemie • Aspect • biomedical engineering • Biomedizintechnik • cases • Central • characterization • Chemie • Chemistry • Clinical Engineering • compounds • Critical • Development • drug products • Due • Field • Form • Industry • Klinisches Ingenieurwesen • Medical Science • Medizin • Number • Optimum • Overwhelming • Pharmaceutical • Pharmaceutical & Medicinal Chemistry • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische u. Medizinische Chemie • Polymorphism • selection • solid • State • Structure
• ISBN-10: 0-470-65935-1 / 0470659351
• ISBN-13: 978-0-470-65935-9 / 9780470659359