Pharmacogenetics and Individualized Therapy (eBook)

Anke-Hilse Maitland-van der Zee, Ann K. Daly (Herausgeber)

eBook Download: PDF

2012
John Wiley & Sons (Verlag)
978-1-118-11646-3 (ISBN)

Infos

The one-stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practices

Pharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level—and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics.

The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.

Including chapters on specific therapeutic areas and clinical aspects, Pharmacogenetics and Individualized Therapy helps readers, whether they're students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics.

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This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.

Autor

ANKE-HILSE MAITLAND-VAN DER ZEE, PHD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands. ANN K. DALY, PHD, is Professor of Pharmacogenetics at Newcastle University, UK.

Inhalt

Pharmacogenetics and Individualized Therapy 1
CONTENTS 7
PREFACE 9
CONTRIBUTORS 11
1. Pharmacogenetics: A Historical Perspective 15
PART I: PHARMACOGENETICS: RELATIONSHIP TO PHARMACOKINETICS AND PHARMACODYNAMICS 27
2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 29
3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 95
4. Pharmacogenetics of Drug Transporters 115
5. Pharmacogenetics of Drug Targets 163
PART II: PHARMACOGENETICS: THERAPEUTIC AREAS 197
6. Cardiovascular Pharmacogenetics 199
7. Pharmacogenetics in Psychiatry 229
8. Pharmacogenetics in Cancer 265
9. Pharmacogenetics of Asthma and COPD 285
10. Pharmacogenetics of Adverse Drug Reactions 309
11. Pharmacogenomics of Inflammatory Bowel Diseases 337
12. Pharmacogenetics of Pain Medication 367
PART III: PHARMACOGENETICS: IMPLEMENTATION IN CLINICAL PRACTICE 389
13. Ethical and Social Issues in Pharmacogenomics Testing 391
PART IV: DEVELOPMENTS IN PHARMACOGENETIC RESEARCH 415
14. High-Throughput Genotyping Technologies for Pharmacogenetics 417
15. Developments in Analyses in Pharmacogenetic Datasets 429
PART V: PHARMACOGENETICS: INDUSTRY AND REGULATORY AFFAIRS 451
16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 453
17. Role of Pharmacogenetics in Registration Processes 475
PART VI: CONCLUSIONS 491
18. Pharmacogenetics: Possibilities and Pitfalls 493
INDEX 499
COLOR PLATES 505

Rezensionen

"This is a well-written book that I highly recommend to
anyone interested in any aspect of personalized
medicine." (Doody's, 24 August
2012)

Produkt-Details

• Erscheint lt. Verlag: 2.4.2012
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Genomforschung u. Proteomik • Genomics & Proteomics • Life Sciences • Medical Science • Medizin • pharmacodynamics, pharmaceuticals, drug disposition, genotyping, genomics, proteomics, genetic analysis, pharmaceutical industry, pharmaceutical regulation • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-11646-1 / 1118116461
• ISBN-13: 978-1-118-11646-3 / 9781118116463