Advances in Enzymology and Related Areas of Molecular Biology, Volume 77 (eBook)

Eric J. Toone (Herausgeber)

eBook Download: PDF | EPUB

2011
John Wiley & Sons (Verlag)
978-0-470-92293-4 (ISBN)

Infos

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.

Inhalt

Contributors.

Preface.

Structure and Mechanism of RND-Type Multidrug Efflux Pumps
(Hiroshi Nikaido).

Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to
Stress and the Modulation of Their Activity by pH, Inhibitors, and
Phenothiazines (Leonard Amaral, Seamus Fanning, and Jean-Marie
Pagès).

Efflux Pumps of the Resistance-Nodulation-Division
Family: A Perspective of Their Structure, Function, and Regulation
in Gram-Negative Bacteria (Mathew D. Routh, Yaramah Zalucki,
Chih-Chia Su, Feng Long, Qijing Zhang, William M. Shafer, and
Edward W. Yu).

The MFS Efflux Proteins of Gram-Positive and Gram-Negative
Bacteria (Massoud Saidijam, Kim E. Bettaney, Dong Leng, Pikyee
Ma, Zhiqiang Xu, Jeffrey N. Keen, Nicholas G. Rutherford, Alison
Ward, Peter J. F. Henderson, Gerda Szakonyi, Qinghu Ren, Ian T.
Paulsen, Ingerid Nes, Jasmin K. Kroeger, and Anne-Brit
Kolsto).

Efflux Pumps as an Important Mechanism for Quinolone Resistance
(Jordi Vila, Anna Fabrega, Ignasi Roca, Alvaro Hernandez, and
Jose Luis Martinez).

Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update
(Ravi D. Barabote, Jose Thekkiniath, Richard E. Strauss,
Govindsamy Vediyappan, Joe A. Fralick, and Michael J. San
Francisco).

A Survey of Oxidative Paracatalytic Reactions Catalyzed by
Enzymes That Generate Carbanionic Intermediates: Implications for
ROS Production, Cancer Etiology, and Neurodegenerative Diseases
(Victoria I. Bunik, John V. Schloss, John T. Pinto, Natalia
Dudareva, and Arthur J. L. Cooper).

Author Index.

Subject Index.

Rezensionen

"With its discussion of current concepts of the biochemical basis
of antibiotic resistance and its impact on modern medicine, this
book will appeal to students, researchers, scientists, and
clinicians interested in the areas of enzymology and mechanism of
bacterial resistance." (Doody's, 26 August 2011)

Produkt-Details

• Erscheint lt. Verlag: 15.8.2011
• Reihe/Serie: Advances in Enzymology - and Related Areas of Molecular Biology
• Reihe/Serie: Advances in Enzymology - and Related Areas of Molecular Biology
• Reihe/Serie: Advances in Enzymology and Related Areas of Molecular Biology
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Schlagworte: ACCESS • Areas • authoritative • Biochemie u. Chemische Biologie • biochemistry • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • clinical microbiology • Development • Discoveries • enzymes • Enzymologie • Enzymology • Field • Historical • Klinische Mikrobiologie • Landmark • Latest • Life Sciences • Medical Science • Medizin • Molecular Biology • Molekularbiologie • Researchers • roles • Seminal • series • Unrivaled • View • Zell- u. Molekularbiologie
• ISBN-10: 0-470-92293-1 / 0470922931
• ISBN-13: 978-0-470-92293-4 / 9780470922934