Inhibitors of Nucleic Acid Synthesis

Biophysical and Biochemical Aspects

H. Kersten, W. Kersten (Autoren)

Buch | Softcover

X, 186 Seiten

2011
Springer Berlin (Verlag)
978-3-642-80857-9 (ISBN)

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During the last decade physical and chemical methods have improved rapidly - a fact which allowed the mode of action of antibiotics to be studied - and many biochemically-oriented scientists have devoted their research to the following questions: 1. What is the metabolic pathway that is inhibited selectively, and what are the target molecules within a sensitive cell? 2. What are the relationships between the chemical structure of an antibiotic and the physicochemical properties of the sensitive mole cule(s)? 3. Why and how far is the action selective? 4. Is it possible to correlate the interaction with the target mole cule(s) with the particular biological activities observed? This monograph deals with those antibiotics which interfere with the biosynthesis of nucleic acids. The idea was to provide an insight into how to investigate the preceding questions experimentally and to solve as yet unresolved problems rather than to give a review of the current state of knowledge. Although the biochemistry of nucleic acid synthesis is known in general, the precise molecular mechanisms by which deoxyribonucleic acid is replicated or transcribed has still to be clarified. For this reason it is not yet possible to describe the molecular mechanisms by which the inhibitors of nucleic acid and protein synthesis exhibit their effects. The fact that the inhibitors of nucleic acid and protein synthesis themselves served as useful tools to obtain an insight into the mechanisms of replication, transcription and translation was one of the most exciting discoveries in this field.

General Introduction.- I. Inhibitors of DNA Synthesis.- A. Mitomycin.- B. Streptonigrin.- C. Sibiromycin.- D. Phleomycin.- E. Bleomycin.- F. Neocarcinostatin.- G. Edeine.- H. Nalidixic Acid.- II. Inhibitors of RNA Synthesis that Interact with the DNA Template.- A. Actinomycin.- B. Anthracyclines.- C. Chromomycin, Olivomycin and Mithramycin.- D. Kanchanomycin.- E. Distamycin and Netropsin.- F. Anthramycin.- III. Inhibitors of RNA Synthesis Interacting with RNA Polymerases.- A. Rifamycins.- B. Streptovaricin.- C. Streptolydigin.- D. Amanitins.- IV. Inhibitors Interferring at the Precursor Level or with Regulatory Processes of Nucleic Acid Synthesis.- A. Nucleoside Antibiotics.- B. Mycophenolic Acid.- C. Amino Acid Analogs.- D. Quinone Antibiotics 1.- References.

Erscheint lt. Verlag	15.12.2011
Reihe/Serie	Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik
Zusatzinfo	X, 186 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	354 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	Antibiotikum • Antimetabolit • biochemical engineering • biochemistry • Biosynthese • Chemistry • Nukleinsäure • Protein • transcription • Translation
ISBN-10	3-642-80857-3 / 3642808573
ISBN-13	978-3-642-80857-9 / 9783642808579
Zustand	Neuware