Mucosal Immunology (eBook)

John Bienenstock, Michael E. Lamm, Lloyd Mayer, Jerry R. McGhee, Jiri Mestecky, Pearay L. Ogra, Warren Strober (Herausgeber)

eBook Download: EPUB

2005 | 3. Auflage
2064 Seiten
Elsevier Science (Verlag)
978-0-08-045426-9 (ISBN)

Infos

Mucosal immunology is so important since most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes. Mucosal Immunology, now in its third edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective and excellent organization. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix

Inhalt

front cover 1
copyright 5
front matter 6
Preface to the First Edition 10
Preface to the Second Edition 12
Preface to the Third Edition 14
Contributors 16
table of contents 28
Historical Aspects of Mucosal Immunology 34
body 58
Part I Mucosal Immune System 58
Section A Mucosal Barrier: Development and Physiology of Mucosal Defense 60
1 Development and Physiology of Mucosal Defense: An Introduction 62
2 Mucosal Microbiota 76
3 Adhesion of Bacteria to Mucosal Surfaces 92
4 Mucus 106
5 Innate Humoral Defense Factors 130
6 Defensins and Other Antimicrobial Peptides and Proteins 152
7 Cellular and Molecular Basis for Antigen Transport Across Epithelial Barriers 168
8 Structure and Function of Intestinal Mucosal Epithelium 188
9 Mucosal Immunoglobulins 210
10 Organization and Expression of Genes Encoding IgA Heavy Chain, Polymeric Ig Receptor, and J Chain 240
11 Phylogeny and Comparative Physiology of IgA 252
12 Immunoglobulin Transport and the Polymeric Immunoglobulin Receptor 268
13 Fc Receptors 308
14 Biological Activities of IgA 324
15 Microbial Evasion of IgA Functions 348
16 Ontogeny of Mucosal Immunity and Aging 362
17 Phylogeny of the Gut-Associated Lymphoid Tissue (GALT) 380
18 The Role of Mucosal Microbiota in the Development, Maintenance, and Pathologies of the Mucosal Immune System 392
Section B Inductive and Effector Tissues and Cells of the Mucosal Immune System 426
19 Inductive and Effector Tissues and Cells of the Mucosal Immune System: An Overview 428
20 Bronchus-Associated Lymphoid Tissues 432
21 Development and Function of Organized Gut-Associated Lymphoid Tissues 442
22 Human Gut-Associated Lymphoid Tissues 464
23 Nasal-Associated Lymphoid Tissue 472
24 Role of Epithelium in Mucosal Immunity 480
25 Role of Epithelial Cells in Mucosal Antigen Presentation 492
26 Antigen Handling and Presentation by Mucosal Dendritic Cells and Macrophages 508
27 Oral Tolerance: Physiologic Basis and Clinical Applications 544
28 Th1/Th2/Th3 Cells for Regulation of Mucosal Immunity, Tolerance, and Inflammation 596
29 Cytotoxic T Cells of the Mucosal Immune System 616
30 Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes 622
31 IgA B Cell Development 640
32 The Human Mucosal B-Cell System 674
33 B-1 Cells and the Mucosal Immune System 712
34 Lymphocyte Homing: Chemokines and Adhesion Molecules in T cell and IgA Plasma Cell Localization in the Mucosal Immune System 724
35 Proinflammatory Cytokines and Signaling Pathways in Intestinal Innate Immune Cells 738
36 Mast Cells In Mucosal Defenses and Pathogenesis 760
37 Eosinophils 774
38 Neuropeptides for Mucosal Immunity 794
Section C Mucosal Immunity and Infection 806
39 Mucosal Immunity and Infection: An Overview 808
40 Bacterial Interactions with Mucosal Epithelial Cells 810
41 Virus Infection of Epithelial Cells 826
42 Mucosal Immunity to Bacteria 840
43 Mucosal Immunity to Viruses 856
44 Mucosal Immune Response to Parasitic Infections 872
45 Parenteral Immunization Induces Mucosal Protection: A Challenge to the Mucosal Immunity Paradigm 888
46 Passive Immunization: Systemic and Mucosal 898
Section D Mucosal Vaccines 910
47 Mucosal Vaccines: An Overview 912
48 Enteric Bacterial Vaccines: Salmonella, Shigella, Vibrio cholerae, Escherichia coli 932
49 Viral Gastroenteritis Vaccines 944
50 Respiratory Bacterial Vaccines 962
51 Respiratory Viral Vaccines 980
52 Mucosal Immunity and Vaccines Against Simian Immunodeficiency Virus and Human Immunodeficiency Virus 994
53 CpG Oligodeoxynucleotides for Mucosal Vaccines 1016
54 Mucosal Adjuvants 1024
55 Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune Stimulating Complexes (ISCOMs) 1044
56 Antigen Delivery Systems II: Development of Live Recombinant Attenuated Bacterial Antigen and DNA Vaccine Delivery Vector Vaccines 1066
57 Recombinant Live Viral Vectors as Vaccines for Mucosal Immunity 1096
58 Transgenic Plants for Mucosal Vaccines 1110
59 Antigen Delivery Systems III: Use of Recombinant Plant Viruses 1118
60 DNA Vaccines for Mucosal Immunity to Infectious Diseases 1130
61 Mucosal Veterinary Vaccines: Comparative Vaccinology 1142
62 Mucosal Vaccines for Dental Diseases 1166
Part II Mucosal Diseases 1196
Section E Immunodeficiency 1198
63 Immunodeficiency and Mucosal Immunity: An Overview 1200
64 Immunodeficiency and Mucosal Immunity 1202
65 Undernutrition, Immunodeficiency, and Mucosal Infections 1216
66 Mucosal Infection and Immune Responses to Simian Immunodeficiency Virus 1236
67 Immunobiology of Mucosal HIV-1 Infection 1256
Section F Stomach, Liver, and Intestine 1270
68 Mucosal Injury and Immunopathology: An Overview 1272
69 Peptic Ulcers and Gastritis 1276
70 Disease Induction and Prevention in Experimental Models of Inflammatory Bowel Disease 1294
71 Ulcerative Colitis: Evolving Insights into Pathogenesis 1312
72 Crohn's Disease: Current Pathogenetic Paradigms 1322
73 Protein-Losing Enteropathies 1344
74 Celiac Disease 1368
75 Food Allergy: Immunophysiology 1392
76 Allergic Diseases in the Gastrointestinal Tract 1408
77 Gastrointestinal Lymphoma 1418
78 Liver and Biliary Tract 1430
79 Systemic Manifestations of Mucosal Diseases: Trafficking of Gut Immune Cells to Joints and Liver 1446
Section G Respiratory Tract 1456
80 Mucosal and Other Mechanisms of Resistance in the Respiratory Tract: An Overview 1458
81 Experimental Models of Airway Hyperresponsiveness 1460
82 Asthma: Clinical Aspects and Mucosal Immunology 1472
83 Clinical Aspects of Bronchial Reactivity and Cell-Virus Interaction 1490
84 Immune Responses to Mycoplasma 1508
85 Local Immune Responses in Tuberculosis 1522
Section H Oral Cavity, Upper Airway, and Head and Neck 1532
86 Ocular Mucosal Immunity 1534
87 Nasal Immunologic Reactivity, Rhinitis, and Polyps 1554
88 Middle Ear and Eustachian Tube 1566
89 Immunology of Diseases of the Oral Cavity 1574
90 Immunobiology of the Tonsils and Adenoids 1604
Section I Genitourinary Tract and Mammary Gland 1630
91 Immunology and Immunopathology of the Genitourinary Tract: An Overview 1632
92 IgA Nephropathy and Related Diseases 1636
93 Urinary Tract Infections and the Mucosal Immune System 1658
94 Female Genital Tract Infections and Immunity in Animal Models 1670
95 Mucosal Immunity in the Human Female Reproductive Tract 1688
96 Human Male Genital Tract Immunity and Experimental Models 1704
97 Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract 1718
98 Immunologically Mediated Male and Female Reproductive Failure 1734
99 Mucosal Immunology of Sexually Transmitted Diseases 1750
100 Maternal Genital Tract Infection and the Neonate 1778
101 Immunity at the Maternal-Fetal Interface 1792
102 Amniotic Fluid and the Fetal Mucosal Immune System 1804
103 Immunoglobulins and Immunocytes in the Mammary Gland and Its Secretions 1820
104 Human Milk: Its Components and Their Immunobiologic Functions 1852
back matter 1886
Appendix I Collection and Processing of Human Mucosal Secretions 1886
Appendix II Collection and Processing of External Secretions and Tissues of Mouse Origin 1898
Appendix III Collection, Handling, and Analysis of Specimens for Studies of Mucosal Immunity in Large Animals 1910
Abbreviations 1926
index 1928
Color Plates 1976

Textauszug

Contributors

Mohammed D. Abd-Alla

Department of Medicine, University of Minnesota, Minneapolis, Minnesota

Soman N. Abraham

Departments of Pathology and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina

David Adams

Liver Research Laboratories, University of Birmingham, Institute of Clinical Science, MRC Centre for Immune Regulation, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom

Deborah J. Anderson

Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham

Women’s Hospital, Harvard Medical School, Boston, Massachusetts

Charles J. Arntzen

Arizona State University Biodesign Institute and School of Life Sciences, Tempe, Arizona

T. Prescott Atkinson

Department of Pediatrics, Division of Pediatric Allergy, University of Alabama at Birmingham, Birmingham, Alabama

Espen S. Baekkevold

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway

A. Dean Befus

Pulmonary Research Group, Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada

Lesley Ann Bergmeier

Guy’s, Kings, and St. Thomas’ Medical and Dental Schools, London, United Kingdom

Göran Bergsten

Department of Medical Microbiology, University of Lund, Lund, Sweden

M. Cecilia Berin

Department of Pediatrics, Mount Sinai School of Medicine, New York, New York

Joel M. Bernstein

Department of Otolaryngology and Pediatrics, State University of New York at Buffalo, School of Biomedical Sciences, Buffalo, New York

Charles L. Bevins

Departments of Immunology, Gastroenterology, and Colorectal Surgery, The Cleveland Clinic Foundation Research Institute, Cleveland, Ohio

John Bienenstock

Departments of Medicine & Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

Brian L. Bishop

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina

Jan Bjersing

Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden

Richard S. Blumberg

Division of Gastroenterology, Harvard Medical School, Brigham

Women’s Hospital, Boston, Massachusetts

Libuse A. Bobek

Department of Oral Biology, University at Buffalo, Buffalo, New York

Nadiya Boiko

Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania

Department of Genetics and Plant Physiology, Uzhhorod National University, Uzhhorod, Ukraine

Nicolaas A. Bos

Department of Cell Biology, Immunology Section, University of Groningen, Groningen, The Netherlands

Kenneth L. Bost

Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina

Prosper N. Boyaka

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama

Per Brandtzaeg

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway

David E. Briles

Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama

Jeremy H. Brock

Department of Immunology, University of Glasgow, Glasgow, Scotland

Richard A. Bronson

Department of Obstetrics and Gynecology, Stony Brook Health Science Center, Stony Brook, New York

William R. Brown

Department of Gastroenterology, University of Colorado School of Medicine, Denver, Colorado

Mark G. Buckley

Allergy and Inflammation Research, Division of Infection, Inflammation, and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom

Eugene C. Butcher

Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California

The Center for Molecular Biology and Medicine, The Veterans Affairs Palo Alto Health Care System, Palo Alto, California

John E. Butler

Department of Microbiology and Interdisciplinary Immunology Program, The University of Iowa, Iowa City, Iowa

Hege S. Carlsen

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway

Gail H. Cassell

Infectious Disease Drug Discovery Research and Clinical Investigation, Lilly Research Laboratories, Indianapolis, Indiana

Sabina Cauci

Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy

John J. Cebra

Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania

Stephen J. Challacombe

Department of Oral Medicine and Pathology, Guy’s Hospital, London, United Kingdom

Hilde Cheroutre

La Jolla Institute for Allergy & Immunology, San Diego, California

Rachel Chikwamba

Arizona State University Biodesign Institute and School of Life Sciences, Tempe, Arizona

Noel K. Childers

Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama

Robert L. Clancy

Department of Pathology, University of Newcastle, Newcastle, New South Wales, Australia

Richard W. Compans

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia

Richard A. Cone

Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland

Lynette B. Corbeil

Department of Pathology, UCSD Medical Center, University of California at San Diego, San Diego, California

Mardi A. Crane-Godreau

Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire

Allan W. Cripps

School of Medicine, Griffith University, Queensland, Australia

Charlotte Cunningham-Rundles

Division of Clinical Immunobiology, Mount Sinai School of Medicine, New York, New York

Roy Curtiss, III.

Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona

Cecil Czerkinsky

Faculte de Medecine-Pasteur, Universite de Nice, Nice, France

Steven J. Czinn

Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio

Ype de Jong

Division of Immunology, Beth Israel Hospital, Boston, Massachusetts

Gordon Dent

Centre for Molecular Biomedicine, School of Life Sciences, Keele University, Keele, United Kingdom

Mark T. Dertzbaugh

United States Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland

Victor J. DiRita

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan

Rainer Duchmann

Medical Department, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Free University of Berlin, Berlin, Germany

Charles O. Elson

Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama

Steven N. Emancipator

Department of Pathology, Case Western Reserve University, Cleveland, Ohio

Mary K. Estes

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas

Sidonia Fargarasan

Laboratory of Mucosal Immunology, RIKEN Research Centre for Allergy and Immunology, Yokohama City, Japan

Ana M.C. Faria

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Inger Nina Farstad

Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathololgy, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway

Paul L. Fidel, Jr.

Department of Microbiology, Louisiana State University Health Science Center, New Orleans, Louisiana

Hans Fischer

Department of Medical Microbiology, University of Lund, Lund, Sweden

George Fogg

Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan

Kohtaro Fujihashi

Departments of Oral Biology and Microbiology, and The Immunobiology Vaccine...

Produkt-Details

• Erscheint lt. Verlag: 2.2.2005
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• ISBN-10: 0-08-045426-7 / 0080454267
• ISBN-13: 978-0-08-045426-9 / 9780080454269