Biomaterials in Blood-Contacting Devices

Complications & Solutions

Meng-Jiy Wang, Wei-Bor Tsai (Autoren)

Buch | Softcover

77 Seiten

2010
Nova Science Publishers Inc (Verlag)
978-1-60876-784-7 (ISBN)

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Introduces the blood components involved in hemostasis and thrombosis, followed by the common biomaterials applied in blood-contacting devices. This book addresses the complications induced by the interactions between blood and biomaterials. It explains the commonly used techniques for improving biomaterials' hemocompatibility.

All blood-contacting medical devices in use today are subjected to some degree poorer blood compatibility than the native artery. Homeostatic mechanism, arresting bleeding from injured blood vessels, induces platelet adhesion and activation onto artificial biomaterials, which leads to undesirable outcomes such as blood clotting at the site of the implant, continual shedding of thrombi, and depletion of platelets from the blood stream. Such complications have hampered the clinical success of blood contacting devices, limiting the patent of small-diameter vascular grafts and making necessary the use of anticoagulants in patients undergoing extracorporeal bypass or synthetic heart valve implantation. Therefore, development of non-thrombogenic biomaterials is in great need for blood contacting devices. The current approaches mainly focus on surface modifications with biological anticoagulants such as heparin, or anti-fouling molecules like poly(ethylene oxide). In this review, the authors first introduce the blood components involved in hemostasis and thrombosis, followed by the common biomaterials applied in blood-contacting devices. Next, the complications induced by the interactions between blood and biomaterials are briefly addressed. Finally, the commonly used techniques for improving biomaterials' hemocompatibility are expatiated.

Abstract; Introduction; Blood Components Involved in Hemostasis & Thrombosis; Platelets; Fibrinogen & von Willebrand Factor; Clotting Factors & Coagulation; Blood flow; Fibrinolysis; Blood-contacting Devices & Materials; Polyurethane (PU) & polyether urethane (PEU); Polyethylene (PE) & polypropylene (PP); Silicone rubbers; Polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene (FEP), & poly(ethylene terephthalate) (PET); Polyvinyl chloride (PVC); Blood-Materials Interactions; Surface modification for improving blood compatibility; Heparin; Hydrophilic surfaces; Phosphorylcholine-based polymers; Zwitterionic surfaces; Clot-dissolving surfaces; Conclusion; References; Index.

Erscheint lt. Verlag	20.5.2010
Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	230 x 155 mm
Gewicht	126 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
Themenwelt	Technik ► Medizintechnik
ISBN-10	1-60876-784-1 / 1608767841
ISBN-13	978-1-60876-784-7 / 9781608767847
Zustand	Neuware