Pluripotent Stem Cells
Nova Science Publishers Inc (Verlag)
978-1-60876-738-0 (ISBN)
Pluripotent cells of the early embryo originate all types of somatic cells and germ cells of adult organism. Pluripotent stems cell lines were derived from mammalian embryos and adult tissues using different techniques and from different sources. Despite different origin, all pluripotent stem cell lines demonstrate considerable similarity of the major biological properties. This book examines the fundamental mechanisms which regulate normal development of pluripotent cells into different lineages and are disrupted in cancer initiating cells. Analysis gene expression profiles, differentiation potentials and cell cycle of normal and mutant pluripotent stem cells provide new data to search molecular targets to eliminate malignant cells in tumours. In this book, the authors also aim to present a global picture of how extracellular signals, intracellular signal transduction pathways and transcriptional networks co-operate together to determine the cell fate of pluripotent stem cells. Practical, ethical and legal considerations that must be addressed before induced pluripotent stem (iPS) cells can realise their potential in the treatment of degenerative disease is discussed as well. Recent advancements in the cancer stem cell hypothesis are also summarised and the challenges associated with targeting resistant cancers in the context of stem cell microenvironments are presented.
Preface; Normal & Pathological Development of Pluripotent Stem Cells; Molecular Mechanism Involved in the Maintenance of Pluripotent Stem Cells ; Generation of Clinically Relevant "Induced Pluripotent Stem" (iPS) Cells ; Amniotic Fluid & Placental Stem Cells; Exploring a Stem Cell Basis to Identify Novel Treatment for Human Malignancies; Outstanding Questions Regarding Induced Pluripotent Stem (iPS) Cell Research; Lepidopteran Midgut Stem Cells in Culture: A New Tool for Cell Biology & Physiological Studies; Are Embryonic Stem Cells Really Needed for Regenerative Medicine?; Genetic Stability of Murine Pluripotent & Somatic Hybrid Cells may be Affected by Conditions of their Cultivation; Recent Advancements towards the Derivation of Immune-Compatible Patient-Specific Human Pluripotent Stem Cell Lines; Pluripotent Cells in Embryogenesis & in Teratoma Formation; Index.
| Zusatzinfo | Illustrations |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 230 x 155 mm |
| Gewicht | 548 g |
| Themenwelt | Medizin / Pharmazie |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 1-60876-738-8 / 1608767388 |
| ISBN-13 | 978-1-60876-738-0 / 9781608767380 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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