Evolution of the Human Genome I

The Genome and Genes

Buch | Softcover

305 Seiten

2019 | Softcover Reprint of the Original 1st 2017 ed.
Springer Verlag, Japan
9784431568315 (ISBN)

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This book reviews the human genome from an evolutionary perspective. No such book has ever been published before, although there are many books on human genomes. There are two parts in this book: Overview of the Human Genome (Part I) and The Human Genome Viewed through Genes (Part II). In Part I, after a brief review of human evolution and the human genome (by Naruya Saitou), chapters on rubbish or junk DNA (by Dan Graur), GC content heterogeneity (by Satoshi Oota), protein coding and RNA coding genes (by Tadashi Imanishi), duplicated genes (by Takashi Kitano), recombinations (by Montanucci and Bertranpetit), and copy number variations including microsatellites (by Naoko Takezaki) are discussed. Readers can obtain various new insights on the human genome from this part. In Part II, genes in X and Y chromosomes (by Yoko Satta and others), HLA genes (by Timothy A. Jinam), opsin genes (by Shoji Kawamura and Amanda D. Melin), genes related to phenotypic variations (by RyosukeKimura), transcription factors (by Mahoko Takahashi and So Nakagawa), diabetes-related genes (by Ituro Inoue), disease genes in general (by Ituro Inoue and Hirofumi Nakaoka), and microbial genomes (by Chaochun Wei) are discussed. The human genome sequences were determined in 2004, and after more than 10 years we are now beginning to understand the human genome from an evolutionary point of view. This book furnishes readers with a good summary of current research in the field.

Naruya Saitou, National Institute of Genetics, Mishima, Japan

Preface.- Part I: Overview of the Human Genome.- Chapter 1: Human evolution and human genome at a glance.- Chapter 2: Rubbish DNA: The functionless fraction of the human genome.- Chapter 3: GC content heterogeneity.- Chapter 4: Protein-coding and non-coding RNA genes.- Chapter 5: Duplicated genes.- Chapter 6: Recombination.-Chapter 7: CNVs and microsatellite DNA polymorphism.-Part II: The Human Genome Viewed through Genes.-Chapter 8: Genes on X and Y chromosomes.- Chapter 9: Human Leukocyte Antigen (HLA) region in human population studies.-Chapter 10: Evolution of genes for color vision and the chemical senses in primates.-Chapter 11: Global landscapes of human phenotypic variation in inherited traits.- Chapter 12: Transcription factor genes.- Chapter 13: Genetics of diabetes: are they thrifty genotype?.- Chapter 14: Disease-related genes from population genetic aspect and their functional significance.- Chapter 15: Microbe genomes associated with human body.-Index.

Erscheinungsdatum	08.04.2019
Reihe/Serie	Evolutionary Studies
Zusatzinfo	39 Illustrations, color; 35 Illustrations, black and white
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Evolution
	Sozialwissenschaften ► Ethnologie
	Sozialwissenschaften ► Soziologie
Schlagworte	Disease • Evolution • genome organization • human genome • Junk DNA • Opsin genes • Primates • recombination • transcription factors
ISBN-13	9784431568315 / 9784431568315
Zustand	Neuware