Isoenzymes

C. C. Rider (Autor)

Buch | Softcover

80 Seiten

1980
Chapman and Hall (Verlag)
978-0-412-15640-3 (ISBN)

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Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, as well as providing indices of aberrant gene expression in carcinogenesis and other pathological processes. Iso enzymes are also being used increasingly in diagnostic clinical bio chemistry. It is surprising that this phenomenon which affects such a high pro portion of enzymes and is clearly important in biochemistry should receive such scant attention in the standard textbooks of that subject, the formal treatment of isoenzymology in these rarely exceeding one or two pages. This may be because the 'pure biochemist' has tended to regard variation in enzyme properties between tissues more as an unwanted complication than as a potential source of insight into diversity of biological function.

1 Introduction.- 2 Structural aspects of isoenzymes.- 3 Isoenzymes in genetics and evolution.- 4 Isoenzymes in development and differentiation.- 5 Isoenzymes in metabolic regulation.- 6 Isoenzymes in cancer.- 7 Isoenzymes in diagnosis and disease.- 8 Separation and determination of isoenzymes.

Erscheint lt. Verlag	30.10.1980
Reihe/Serie	Outline Studies in Biology
Zusatzinfo	16 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	140 x 216 mm
Themenwelt	Geisteswissenschaften
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zoologie
	Sozialwissenschaften
ISBN-10	0-412-15640-7 / 0412156407
ISBN-13	978-0-412-15640-3 / 9780412156403
Zustand	Neuware