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Interplay between Metal Ions and Nucleic Acids

Astrid Sigel, Helmut Sigel, Roland KO Sigel (Herausgeber)

Buch | Hardcover

354 Seiten

2012 | 2012
Springer (Verlag)
978-94-007-2171-5 (ISBN)

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Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution. - 2. Nucleic Acid-Metal Ion Interactions in the Solid State. - 3. Metal Ion-Promoted Conformational Changes of Oligonucleotides. - 4. G-Quadruplexes and Metal Ions. - 5. Metal Ion-Mediated DNA-Protein Interactions. - 6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids. - 7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes. - 8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors. - 9. Enantioselective Catalysis at the DNA Scaffold. - 10. Alternative DNA Base Pairing through Metal Coordination. - 11. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides. - 12. Metal Complex Derivatives of Peptide Nucleic Acids.

Erscheint lt. Verlag	3.1.2012
Reihe/Serie	Metal Ions in Life Sciences ; 10
Zusatzinfo	XXXIV, 354 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Schulbuch / Wörterbuch
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Chemie ► Analytische Chemie
	Naturwissenschaften ► Chemie ► Anorganische Chemie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Sozialwissenschaften ► Pädagogik
	Technik ► Maschinenbau
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	biosensors • DNA • metal ion-nucleic acid interactions • Peptide nucleic acids (PNA • RNA
ISBN-10	94-007-2171-4 / 9400721714
ISBN-13	978-94-007-2171-5 / 9789400721715
Zustand	Neuware