New Trends in Cross-Coupling (eBook)

Theory and Applications

Thomas Colacot (Herausgeber)

eBook Download: PDF

2014
864 Seiten
Rsc (Verlag)
9781782620259 (ISBN)

Infos

Palladium-catalysed cross-coupling reactions constitute a powerful class of chemical methods for the creation of carbon-carbon and carbon-heteroatom bonds used in organic synthesis, famously recognized by the 2010 Nobel Prize awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki 'for palladium-catalysed cross-couplings in organic synthesis.' These methods have become ubiquitous in academic and industrial settings alike, as applications span from industrial production of pharmaceuticals, agrochemicals, polymers, and dyes to the synthesis of complex natural products.New Trends in Cross-Coupling provides the reader with the history and basic, concepts of cross-coupling up to the state of the art in modern coupling reactions from both technology and applied perspectives. A wide breadth of topics including selecting prominent ligand types; advances in Pd-phosphine precatalysts and Pd N-heterocyclic carbene complexes; new reactions such as carboiodination; implementation of new technologies such as continuous flow and advanced metal detection methods; greener approaches to cross-coupling; as well as large-scale applications in the syntheses of pharmaceutical materials are covered.Edited by Thomas J. Colacot, an Industrial expert on cross coupling, the book contains contributions from academic and industrial world leaders in the field as well as a Forewords from Professor Barry M. Trost, Gregory C. Fu and 2010 Nobel Laureate in Chemistry Professor Ei-ichi Negishi. New Trends in Cross-Coupling serves as a reference guide for both undergraduate and graduate students as well as those who are experts in the area.'...this compilation, a Must for anyone interested in learning and using newer trends in cross-coupling.' Ei-ichi Negishi, 2010 Nobel Laureate in Chemistry'I am very pleased to see such a book concerning cross coupling reactions published.' Professor Akira Suzuki - 2010 Nobel Laureate in Chemistry.'this book is invaluable to anyone involved in synthesis of organic compounds for any purpose.' Professor Barry Trost, Stanford University.

Inhalt

Introduction to New Trends in Cross-Coupling; Prominent Ligand Types in Modern Cross-Coupling Reactions; Pd–Phosphine Precatalysts for Modern Cross-Coupling Reactions; Advances in C–C and C–X Coupling Using Palladium–NHeterocyclic Carbene (Pd–NHC) Complexes; Ancillary Ligand Design in the Development of Palladium Catalysts for Challenging Selective Monoarylation Reactions; Transition Metal-Catalyzed Formation of C–O and C–S Bonds; Pd(0)-Catalyzed Carboiodination: Early Developments and Recent Advances; Boron Reagent Activation in Suzuki–Miyaura Coupling; Modern Heck Reactions; Palladium-Catalysed Carbonylative Coupling and C–H Activation; Stereospecific and Stereoselective Suzuki–Miyaura Cross-Coupling Reactions; Direct Arylation via C–H Activation; Cross-Coupling Chemistry in Continuous Flow; Greener Approaches to Cross-Coupling; Recent Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals; Palladium Detection Techniques for Active Pharmaceutical Ingredients Prepared via Cross-Couplings;

Produkt-Details

• Erscheint lt. Verlag: 13.10.2014
• Reihe/Serie: Catalysis Series
• Reihe/Serie: ISSN
• Reihe/Serie: ISSN
• Verlagsort: Cambridge
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Beruf / Finanzen / Recht / Wirtschaft ► Wirtschaft
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Physikalische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• Schlagworte: Applications • coupling • Cross • New • theory • Trends
• ISBN-13: 9781782620259 / 9781782620259