Guanidines 2

Further Explorations of the Biological and Clinical Significance of Guanidino Compounds

Akitane Mori (Autor)

Buch | Softcover

365 Seiten

2011
Springer-Verlag New York Inc.
978-1-4612-8099-6 (ISBN)

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Guanidine is named for its similarity to the purine guanine which, in turn, is named for its principal source guano, which comes from the Inca word, huano, for dung. Guanidine, therefore, translates into dung-like, which is hardly a genteel way to introduce a subject. On the other hand, texts are seldom inspirational, "frequently crude and rarely literary and should be judged on how successfully they assemble, organize and present current data. I am impressed that the material which fol]ows goes a long way toward successfully achieving those goals. Tue International Guanidine Society is a synthesis of three groups of investigators: biologists studying guanidines as phosphagens, neurologists interested in guanidines as convulsants and nephrologists involved with guanidines as toxins. As a member of the latter group. I am gratified by the considerable progress this book represents. To begin with. there now appears to be a common theme which unifies current speculation concerning the metabolic origin of the guanidines in uremia. At the First International Congress in 1983, evidence was presented which supported the theory that certain guanidines were products of the mixed function oxidation of urea. This year's meeting brings together overwhelming data showing that methyl guanidine is an effect of active oxygen reacting with creatinine. An idolatry, worshipped throughout biochemistry, that urea and creatinine are inert byproducts of protein metabolism, is shown to have feet of clay.

I. Analytical Method for Guanidino Compounds and New Guanidino Compounds.- Enzymic Determination of Methylguanidine in Serum and Plasma of Hemodialysis Patients as a Marker for Hydroxyl Radicals.- Measurement of Creatine and Phosphocreatine in Muscle Tissue Using HPLC.- ?-Guanidinooxypropylamine and NG-Methylagmatine: Novel Guanidinoamines Found in Seeds of Leguminous Plants.- Phascoline and Phascolosomine: New Catabolic Products of Pyrimidines in Sipunculid Worms.- II. Metabolism of Guanidino Compounds.- Effects of Arginine-Free Diet on Ureagenesis in Young and Adult Ferrets.- Serum and Urinary Guanidino Compounds in “Sparse-fur” Mutant Mice with Ornithine Transcarbamylase Deficiency.- Biosynthesis of 2-Guanidinoethanol.- The Existence of Multiple Forms of Rat Kidney Transamidinase.- Puromycin Aminonucleoside Stimulates the Synthesis of Methylguanidine: A Possible Marker of Active Oxygen Generation in Isolated Rat Hepatocytes.- Active Oxygen in Methylguaftidine Synthesis by Isolated Rat Hepatocytes.- Effect of Active Oxygen on Guanidine Synthesis in vitro.- The Reactivity of Guanidino Compounds with Hydroxyl Radicals.- III. Physiological, Pharmacological and Toxicological Aspects of Guanidino Compounds.- Guanidines as Drugs.- Dimethylarginine Has Digitalis Like Activity.- Adenosine, Adenosine Analogues and Their Potentiators Inhibit Methylguanidine Synthesis, a Possible Marker of Active Oxygen in Isolated Rat Hepatocytes.- The Alteration of Guanidino Compounds in the Liver, Kidney and Blood Following Halothane Inhalation in Rats.- Amelioration of Guanidinoacetic Acid Metabolism in Streptozotocin-Induced Diabetic Rats by Insulin Treatment.- Urinary Excretion Rate of Guanidinoacetic Acid in Essential Hypertension.- Guanidino Compounds in Hemorrhagic Shock.- Effectof Guanidino Compounds on GABA-Stimu1ated Chloride Influx into Membrane Vesicles from Rat Cerebral Cortex.- Effect of Immersion Stress on Guanidino Compounds in Rat Organs and Urine.- IV. Involvement of Seizure Mechanism.- Effects of Anticonvulsants on Convulsive Activity Induced by 2-Guanidinoethanol.- Effect of Guanidinoethane Sulfonate on the Genetically Seizure Susceptible Rat.- Guanidinoethane Sulfonate and the Investigation of Taurine and Other Neuroactive Amino Acids.- Guanidino Compounds in Audiogenic Sensitive Rats.- Guanidino Compounds in Serum and Cerebrospinal Fluid of Epileptic and Some Other Neurological Patients.- The Involvement of Catecholamines in the Seizure Mechanism Induced by a-Guanidinoglutaric Acid in Rats.- V. Hyperargininemia.- Hyperargininemia.- Neurotoxicity of Guanidino Compounds in Hyperargininemia.- Serum Guanidinosuccinic Acid Levels in Urea Cycle Diseases.- a-Keto-6-guanidinovaleric Acid, a Compound Isolated fromHyperargininemic Patients, Displays Epileptogenic Activities.- VI. Involvement of Giuanidino Compounds in Renal Dysfunction.- Serum Levels of Guanidino Compounds in Acute Renal Failure.- Is Guanidine a Marker of Peroxidation in Uremics?.- Disturbance of Creatine Metabolism in Rats with Chronic Renal Failure.- Changes in Urinary Me thyIguanidine in Cases with End-stage Renal Disease.- The Role of Non-protein Nitrogen in Progressive Renal Failure.- Urinary Guanidinoacetic Acid Excretion as an Indicator of Gentamicin Nephrotoxicity in Rats.- Effect of Antibiotic Administration on Urinary Guanidinoacetic Acid Excretion in Renal Disease.- Metabolism of Guanidinoacetic Acid in Renal Tubular Tissue Culture: A Model System for Cisplatin Nephropathy.- Short-Term Protein Load in Assessment of Guanidinoacetic Acid Synthesis in Patients with Chronic Renal Failure.- The Significance of Serum and Urinary Guanidinoacetic Acid Level for the Restoration of Renal Metabolic Function in Patients with Kidney Transplantation.- Contributors.- Index: Guanidines in Organs.

Zusatzinfo	365 p.
Verlagsort	New York
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Sachbuch/Ratgeber ► Natur / Technik ► Naturführer
	Naturwissenschaften ► Biologie ► Zoologie
	Naturwissenschaften ► Chemie
ISBN-10	1-4612-8099-0 / 1461280990
ISBN-13	978-1-4612-8099-6 / 9781461280996
Zustand	Neuware