Regenerative Biology and Medicine (eBook)

David L. Stocum (Autor)

eBook Download: EPUB

2010 | 1. Auflage
464 Seiten
Elsevier Science (Verlag)
978-0-08-049302-2 (ISBN)

Infos

The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.
As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine.
*Tissues covered include skin, hair, teeth, cornea, and central neural types
*Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular
*Includes amphibians as powerful research models
*Discusses appendage regeneration in amphibians and mammals

Inhalt

Front cover 1
Title page 4
Copyright page 5
Table of Contents 6
Preface 10
Chapter 1: An Overview of Regenerative Biology and Medicine 12
Introduction 12
A Brief History of Regenerative Biology and Medicine 13
The Biology of Regeneration 15
Strategies of Regenerative Medicine 22
Summary 28
References 29
Chapter 2: Repair of Skin Wounds by Fibrosis 32
Introduction 32
Structure of Adult Mammalian Skin 32
The Effect of Wound Type and Extent on Dermal Repair 34
Phases of Repair in Excisional Wounds 34
Molecular Comparison of Wounded vs. Unwounded Skin 42
Fetal Skin Heals Without Scarring 43
Summary 46
References 47
Chapter 3: Regeneration of Epidermal Tissues 52
Introduction 52
Regeneration of Epidermis and Hair 52
Regeneration of Nails 58
Regeneration of Dental Tissues 59
Regeneration of the Lens 61
Regeneration of the Cornea 67
Summary 68
References 69
Chapter 4: Regenerative Medicine of Skin, Hair and Dental Tissues 74
Introduction 74
Repair of Skin 74
Repair of Teeth and Peridontium 87
Corneal Regeneration 89
Summary 93
References 94
Chapter 5: Regeneration of Neural Tissues 100
Introduction 100
Axon Regeneration 100
Maintenance Regeneration of Neurons in the Mammalian CNS 110
Injury-Induced CNS Regeneration 114
Summary 126
References 128
Chapter 6: Regenerative Medicine of Neural Tissues 136
Introduction 136
Therapies for Injured Peripheral Nerve 136
Therapies for Injured Spinal Cord 138
Therapies for Neurodegenerative Diseases 151
Summary 167
References 169
Chapter 7: Regeneration of Digestive, Respiratory and Urogenital Tissues 178
Introduction 178
Intestinal Epithelium 178
Liver 181
Pancreas 188
Alveolar Epithelium of the Lung 192
Kidney and Urinary System 194
Gonads 199
Prostate Tissue 199
Summary 200
References 201
Chapter 8: Regenerative Medicine of Digestive, Respiratory and Urinary Tissues 208
Introduction 208
Regenerative Therapies for the Liver 208
Regenerative Therapies for the Pancreas 212
Regenerative Therapies for the Esophagus and Intestine 218
Regenerative Therapies for the Respiratory System 220
Regenerative Therapies for the Urinary System 221
Summary 225
References 227
Chapter 9: Regeneration of Musculoskeletal Tissues 232
Introduction 232
Regeneration of Skeletal Muscle 232
Regeneration of Bone 240
Repair of Articular Cartilage 250
Repair of Tendon and Ligament 252
Summary 253
References 255
Chapter 10: Regenerative Medicine of Musculoskeletal Tissues 262
Introduction 262
Regenerative Therapies for Muscle 262
Regenerative Therapies for Meniscus and Articular Cartilage 265
Regenerative Therapies for Bone 273
Regenerative Therapies for Tendon and Ligament 283
Summary 285
References 287
Chapter 11: Regeneration of Hematopoietic and Cardiovascular Tissues 294
Introduction 294
Regeneration of Hematopoietic Cells 294
Regeneration of Blood Vessels 298
Regeneration of Cardiac Muscle 303
Summary 310
References 311
Chapter 12: Regenerative Medicine of Hematopoietic and Cardiovascular Tissues 316
Introduction 316
Therapies for Hematopoietic Disorders 316
Therapies for Blood Vessel Regeneration 323
Therapies for Protection and Regeneration of the Infarcted Myocardium 328
Summary 339
References 340
Chapter 13: Regenerative Medicine: Developmental Plasticity of Adult Stem Cells 348
Introduction 348
Assays to Test Developmental Plasticity 348
Experimental Results 349
Many Reports of Lineage Conversion are Due to Fusion With Host Cells 360
Adult Stem Cell Pluripotency: Fact or Fiction? 361
Effects of Aging on Number and Developmental Status of Regeneration-Competent Cells 362
Summary 367
References 369
Chapter 14: Regeneration of Appendages 374
Introduction 374
Amphibian Limb Regeneration 374
Regeneration of Amphibian Jaws 396
Appendage Regeneration in Mammals 397
Summary 406
References 407
Chapter 15: Research Issues in Regenerative Medicine 416
Introduction 416
Biological Issues and Challenges. 417
Bioethical Issues and Challenges 431
Concluding Remarks 436
Summary 437
References 438
Index 444

Produkt-Details

• Erscheint lt. Verlag: 26.7.2010
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Medizintechnik
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• ISBN-10: 0-08-049302-5 / 0080493025
• ISBN-13: 978-0-08-049302-2 / 9780080493022