Principles of Molecular Virology (Standard Edition) (eBook)

Alan J. Cann (Autor)

eBook Download: PDF

2005 | 4. Auflage
352 Seiten
Elsevier Science (Verlag)
978-0-08-047072-6 (ISBN)

Infos

Principles of Molecular Virology, Fourth Edition provides an essential introduction to modern virology in a clear and concise manner. It is a highly enjoyable and readable text with numerous illustrations that enhance the reader's understanding of important principles.

* New material on virus structure, virus evolution, zoonoses, bushmeat, SARS and bioterrorism
* Standard version includes CD-ROM with FLASH animations, virtual interactive tutorials and experiments, self-assessment questions, useful online resources, along with the glossary, classification of subcellular infectious agents and history of virology

Inhalt

Cover 1
QUOTES FROM REVIEWS OF PREVIOUS EDITIONS 2
CONTENTS 7
PREFACE TO THE FOURTH EDITION 10
PREFACE TO THE THIRD EDITION 11
PREFACE TO THE SECOND EDITION 12
PREFACE TO THE FIRST EDITION 13
THE PRINCIPLES OF MOLECULAR VIROLOGY CD 15
CHAPTER 1: INTRODUCTION 17
VIRUSES ARE DISTINCT FROM LIVING ORGANISMS 18
THE HISTORY OF VIROLOGY 19
LIVING HOST SYSTEMS 21
CELL CULTURE METHODS 23
SEROLOGICAL/IMMUNOLOGICAL METHODS 25
ULTRASTRUCTURAL STUDIES 28
‘MOLECULAR BIOLOGY’ 34
FURTHER READING 40
CHAPTER 2: PARTICLES 41
THE FUNCTION AND FORMATION OF VIRUS PARTICLES 41
CAPSID SYMMETRY AND VIRUS ARCHITECTURE 44
ENVELOPED VIRUSES 55
COMPLEX VIRUS STRUCTURES 58
PROTEIN–NUCLEIC ACID INTERACTIONS AND GENOME PACKAGING 65
VIRUS RECEPTORS: RECOGNITION AND BINDING 69
OTHER INTERACTIONS OF THE VIRUS CAPSID WITH THE HOST CELL 69
SUMMARY 70
FURTHER READING 70
CHAPTER 3: GENOMES 72
THE STRUCTURE AND COMPLEXITY OF VIRUS GENOMES 72
MOLECULAR GENETICS 75
VIRUS GENETICS 78
VIRUS MUTANTS 80
SUPPRESSION 83
GENETIC INTERACTIONS BETWEEN VIRUSES 84
NONGENETIC INTERACTIONS BETWEEN VIRUSES 87
‘LARGE’ DNA GENOMES 89
‘SMALL’ DNA GENOMES 91
POSITIVE-STRAND RNA VIRUSES 94
NEGATIVE-STRAND RNA VIRUSES 98
SEGMENTED AND MULTIPARTITE VIRUS GENOMES 100
REVERSE TRANSCRIPTION AND TRANSPOSITION 103
EVOLUTION AND EPIDEMIOLOGY 114
SUMMARY 117
FURTHER READING 117
CHAPTER 4: REPLICATION 118
OVERVIEW OF VIRUS REPLICATION 118
INVESTIGATION OF VIRUS REPLICATION 120
THE REPLICATION CYCLE 124
SUMMARY 145
FURTHER READING 145
CHAPTER 5: EXPRESSION 147
EXPRESSION OF GENETIC INFORMATION 147
CONTROL OF PROKARYOTE GENE EXPRESSION 148
CONTROL OF EXPRESSION IN BACTERIOPHAGE l 149
CONTROL OF EUKARYOTE GENE EXPRESSION 154
TRANSCRIPTIONAL CONTROL OF EXPRESSION 166
POSTTRANSCRIPTIONAL CONTROL OF EXPRESSION 171
SUMMARY 179
FURTHER READING 180
CHAPTER 6: INFECTION 181
VIRUS INFECTIONS OF PLANTS 182
IMMUNE RESPONSES TO VIRUS INFECTIONS IN ANIMALS 185
VIRUSES AND APOPTOSIS 190
INTERFERONS 193
EVASION OF IMMUNE RESPONSES BY VIRUSES 197
VIRUS–HOST INTERACTIONS 199
THE COURSE OF VIRUS INFECTIONS 208
VIRUS VECTORS AND GENE THERAPY 215
CHEMOTHERAPY OF VIRUS INFECTIONS 216
SUMMARY 222
FURTHER READING 222
CHAPTER 7: PATHOGENESIS 224
MECHANISMS OF CELLULAR INJURY 226
VIRUSES AND IMMUNODEFICIENCY 228
VIRUS-RELATED DISEASES 237
BACTERIOPHAGES AND HUMAN DISEASE 240
CELL TRANSFORMATION BY VIRUSES 241
VIRUSES AND CANCER 252
NEW AND EMERGENT VIRUSES 256
ZOONOSES 262
BIOTERRORISM 263
SUMMARY 264
FURTHER READING 264
CHAPTER 8: SUBVIRAL AGENTS: GENOMES WITHOUT VIRUSES, VIRUSES WITHOUT GENOMES 265
SATELLITES AND VIROIDS 265
PRIONS 269
SUMMARY 283
FURTHER READING 283
APPENDIX 1: GLOSSARY AND ABBREVIATIONS 285
APPENDIX 2: CLASSIFICATION OFSUBCELLULAR INFECTIOUSAGENTS 297
APPENDIX 3: THE HISTORY OF VIROLOGY 310
INDEX 316

Produkt-Details

• Erscheint lt. Verlag: 9.8.2005
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• ISBN-10: 0-08-047072-6 / 0080470726
• ISBN-13: 978-0-08-047072-6 / 9780080470726