Ubiquitin Proteasome System in CNS Neurodegenerative Diseases

Buch | Hardcover

377 Seiten

2026
Springer Verlag, Singapore
9789819560981 (ISBN)

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This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems.

The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.

Dr. Sarika Singh completed her master's in biochemistry and a Ph.D. in the role of nitric oxide in the pathology of Parkinson’s disease from Lucknow University, Lucknow, India. She is working as a senior principal scientist and Professor at the Academy of Scientific and Innovative Research (AcSIR) at CSIR-Central Drug Research Institute in Lucknow, Uttar Pradesh, India. Dr. Singh’s major research focuses on identifying diagnostic markers and novel signaling factors participate in neurodegeneration. She is actively involved in search for novel therapeutic molecule for management of Alzheimer’s and Parkinson’s diseases. Her exploratory studies target the contributions of bioenergetics and unfolded protein responses in neurodegenerative conditions. She has published over 85 articles in peer-reviewed national and international journals and is an editorial board member and reviewer for various journals. Dr. Singh is a lifetime member of the Indian Academy of Neurosciences and the National Academy of Sciences.

Section I: Introduction to Ubiquitin Proteasome System (UPS).- Chapter 1: Ubiquitin Proteasome System (UPS): Role in Cellular Physiology.- Chapter 2: Ubiquitin Proteasome System (UPS) and Molecular Chaperones.- Chapter 3: Ubiquitin Proteasome System (UPS) and Energy Bioenergetics.- Section II: Signaling Mechanisms in Ubiquitin Proteasome System (UPS).- Chapter 4: Protein Homeostasis and Ubiquitin Proteasome System (UPS).- Chapter 5: Neuroinflammation and Ubiquitin Proteasome System (UPS).- Chapter 6: Endoplasmic Reticulum and Ubiquitin Proteasome System (UPS).- Chapter 7: Triggers of Ubiquitin Proteasome System (UPS): Disease Aspects.- Chapter 8: Ubiquitin Signaling in Central Nervous System (CNS) Neurodegenerative Diseases.- Chapter 9: E3 Ubiquitin Ligases in Central Nervous System (CNS) Neurodegenerative Diseases.- Chapter 10: Deubiquitinating Enzymes in Central Nervous System (CNS) Neurodegenerative Disease.- Chapter 11: Proteasome Machinery in Neurodegenerative Signaling.- Section III: Therapeutic Options for Ubiquitin Proteasome System (UPS).- Chapter 12: Targeting Ubiquitin Proteasome System (UPS) by Natural Products.- Chapter 13: Inhibitors of Protein Aggregates.- Chapter 14: HDAC Inhibitors on Protein Quality Control System.- Section IV: Experimental Tools for Ubiquitin Proteasome System (UPS).- Chapter 15: Animal Models of Disease.- Chapter 16: Pros and Cons of Sporadic Versus Genetic Models of Diseases.

Erscheint lt. Verlag	11.3.2026
Zusatzinfo	17 Illustrations, color; 1 Illustrations, black and white
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
Schlagworte	Alzheimer's signaling pathway • Animal models for Parkinson's disease (PD) • Animal Models of Alzheimer's disease (AD) • E3 ubiquitin ligases in Alzheimer’s pathology • E3 ubiquitin ligases in Parkinson’s pathology • Mechanisms of protein degradation • Parkinson's signaling pathway • Protein homeostasis in neurodegenerative diseases • Proteolysis in neurodegenerative diseases • Ubiquitin–proteasome Syatem (UPS) in Alzheimer's diseases (AD) • Ubiquitin–proteasome Syatem (UPS) in Parkinson's diseases (PD) • Ubiquitin signalling in neurodegenerative diseases
ISBN-13	9789819560981 / 9789819560981
Zustand	Neuware