Introduction to Pharmaceutical Analytical Chemistry (eBook)

Bente Gammelgaard, Trine G. Halvorsen, Stig Pedersen-Bjergaard (Autoren)

eBook Download: EPUB

2025 | 3. Auflage
838 Seiten
Wiley (Verlag)
9781394263318 (ISBN)

Infos

Primary source for learning pharmaceutical analytical chemistry, fully updated and revised to reflect current practice and Pharmacopoeia standards

Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques, and applications of the chemical analysis of pharmaceutical substances, final pharmaceutical products, and drug substances in biological fluids.

Extensively revised throughout to reflect the current European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP), this Third Edition presents updated methodologies, practical examples, and calculations to reflect current pharmaceutical laboratory practice. Revisions to the chapter structure, text, and figures have been implemented to improve clarity and comprehension. New practice problems, up-to-date practical examples, and detailed illustrations are also included throughout the text.

Written by a team of experienced academics, Introduction to Pharmaceutical Analytical Chemistry explores topics including:

• Pharmacopoeias and the link between pharmaceuticals and analytical chemistry
• Fundamentals of bases, acids, solubility, polarity, partition, and stereochemistry
• Titration, UV-Vis spectrophotometry, IR spectrophotometry, and atomic spectrometry
• High-performance liquid chromatography, gas chromatography, electrophoretic methods, and mass spectrometry
• Quantitation, quality of analytical data, and validation
• Chemical analysis of pharmaceutical substances and products including biopharmaceuticals
• Sample preparation and determination of pharmaceutical substance in biological samples

Introduction to Pharmaceutical Analytical Chemistry is essential reading for undergraduate and graduate students enrolled in pharmaceutical courses, along with chemists, biochemists, and other scientists entering the pharmaceutical industry.

Stig Pedersen-Bjergaard is Professor at the Department of Pharmacy, University of Oslo, Norway and at the Department of Pharmacy, University of Copenhagen, Denmark.

Bente Gammelgaard is Professor at the Department of Pharmacy, University of Copenhagen, Denmark.

Trine G. Halvorsen is Professor at the Department of Pharmacy, University of Oslo, Norway.
The authors have long teaching and research experiences in pharmaceutical analytical chemistry.

Textauszug

Symbols and Units

The units in the book are not strictly following the SI units. The units are adjusted to the dimensions in analytical work.

Symbol		Unit

A

Absorbance

–

A(1%, 1 cm)

Specific absorbance

–

AS

Symmetry factor

–

AU

Absorbance units

–

a

Activity

–

α

Relative retention (separation factor)

–

Specific optical rotation

(o) degrees

c

Concentration

g/L, mol/L

d

Dextrorotary (optical rotation)

o (degrees)

D

Distribution ratio (also named distribution coefficient or partition coefficient)

–

E

Potential

V

E

Electrical field (CE)

V/cm

E0

Standard electrode potential (standard reduction potential)

V

ε

Molar absorption coefficient

cm−1 · mol‐1 · L

εo

Relative elution strength

–

η

Viscosity

cPoise

F

Flow rate (chromatography)

mL/min

F

Fluorescence

–

h

Peak height

mm

H

Height Equivalent to Theoretical Plate

mm

I

Intensity

–

IA

Acid value

mg

II

Iodine value

mg

IOH

Hydroxyl value

mg

IS

Saponification value

mg

Ka

Acid ionisation constant (= acid dissociation constant, acidity constant)

Kb

Base ionisation constant (= basicity constant)

KD

Partition ratio (= Distribution constant)

Ksp

Solubility product

Kw

Autoproteolysis equilibrium constant of water (= ion product of water)

k

Retention factor

–

λ

Wavelength

nm

L

Length

m (mm)

l

Levorotary (optical rotation)

o (degrees)

μapp

Apparent mobility

cm2 · min−1 · V−1

μe

Electrophoretic mobility

cm2 · min−1 · V−1

μeo

Electroosmotic mobility

cm2 · min−1 · V−1

M

Molarity

mol/L

M

Molar mass

g/mol

M

Molecular mass

u = Da

Mr

Relative molar mass

–

N

Number of theoretical plates

–

ν

Frequency

Hz (s−1)

pI

Isoelectric point

–

P

Distribution ratio between 1‐octanol and aqueous solution

–

P′

Polarity index

–

ϕ

Quantum yield (fluorescence)

–

r

Radius

m (mm)

Rf

Retention factor (TLC)

–

RS

Resolution (chromatography)

–

ρ

Density

g/cm3

σ

Standard deviation

–

s

Standard deviation

T

Temperature

K, C

T

Transmittance

–

tR

Retention time

min

tM

Hold‐up time

min

t'R

Adjusted retention time

min

u

Atomic mass units

u

u

Linear velocity (flow rate)

cm/s

v

Velocity

m/s

V

Volume

L, 1 mL = 1 cm3

VM

Hold‐up volume (void volume) (LC); Total permeation volume (SEC)

mL

V0

Exclusion volume

mL

VR

Retention volume

mL

W

Peak width

min

Wh

Peak width at half height

min

Mean

–

z

Charge

–

Constants

Avogadros number

N

6.0221 · 1023 mol−1

Faraday's constant

F

9.649 · 104 · C(oulomb) · mol−1 = 96.485 kJ · mol−1

Gas constant

R

8.314 J · K‐1 · mol−1

Speed of light in vacuum

c

2.998 · 108 m/s

Planck's constant

h

6.626 · 10−34 J · s

Greek alphabet

Upper case	Lower case	Name	English

A

α

Alpha

a

B

β

Beta

b

Γ

γ

Gamma

g

Δ

δ

Delta

d

E

ε

Epsilon

e

Z

ζ

Zeta

z

H

η

Eta

h

Θ

θ

Theta

th

I

ι

Iota

i

K

κ

Kappa

k

Λ

λ

Lambda

l

M

μ

Mu

m

N

ν

Nu

n

Ξ

ξ

Xi

x

O

o

Omicron

o

Π

π

Pi

p

P

ρ

Rho

r

Σ

σ

Sigma

s

T

τ

Tau

t

Y

υ

Upsilon

u

Φ

ϕ

Phi

ph

X

χ

Chi

ch

Ψ

ψ

Psi

ps

Ω

ω

Omega

o

Abbreviations

AAS

Atomic Absorption Spectrometry

ADME

...

Produkt-Details

• Erscheint lt. Verlag: 5.11.2025
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• ISBN-13: 9781394263318 / 9781394263318