Textbook of Nephro-Endocrinology

Ajay K. Singh, Gordon H. Williams (Herausgeber)

Buch | Hardcover

570 Seiten

2026 | 3rd edition
Academic Press Inc (Verlag)
978-0-443-21751-7 (ISBN)

Infos

Textbook of Nephro-Endocrinology, Third edition remains the definitive translational reference in the field of nephroendocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephroendocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism.

Since the publication of the 2nd edition in 2009 there have many updates and new findings have emerged. The new edition covers these needed updates and new chapters have been added including a dedicated chapter on the pathophysiology of inflammation, iron metabolism and erythropoiesis, mineralocorticoid receptor antagonists, the treatment of pre-eclampsia, and HIF-PHIs.

Autor

Dr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University. Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology.

Inhalt

1. Erythropoietin: A Historical Overview of Physiology, Molecular Biology, and Gene Regulation
2. Erythropoiesis: The Roles of Erythropoietin and Iron
3. Extra-Hematopoietic Action of Erythropoietin
4. Development of Recombinant Erythropoietin and Erythropoietin Analogs
5. Erythropoietin. Anemia and Kidney Disease
6. Novel Erythropiesis Stimulating Agents
7. Vitamin D and the Kidney: Introduction and Historical Perspective
8. Vitamin D: Molecular Biology and Gene Regulation
9. Molecular Biology of Parathyroid Hormone *& Calcium Sensing?
10. Endocrine Regulation of Phosphate Homeostatis
11. Clinical Syndromes of Vitamin D and Phosphate Dysregulation
12. The Renin-Angiotensin System; History and Introduction
13. Molecular Biology of Renin and Regulation of its Gene
14. Physiology and Regulation of the Renin-Angiotensin-Aldosterone System
15. The Renin-Angiotensin System and the Kidney
16. The Renin-Angiotensin System and the Heart
17. Renin-Angiotensin Blockade: Therapeutic Agents (Hypertension)
18. Vasopressin in the Kidney: Historical Asptects
19. Molecular Biology and Gene Regulation of Vasopressin
20. Vasopressin Antagonists in Physiology and Disease
21. Diabetes Insipidus and SIADH
22. ANP, BNP, and CNP: Physiology and Pharmacology of the Cardiorenal Axis
23. Aldosterone: History and Introduction
24. Aldosterone Mechanism of action: genomic and non-genomic
25. Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation
26. Aldosterone and Its Cardiovascular Effects
27. Novel mineralocorticoid Receptor Antagonists
28. Regulation of Aldosterone Production
29. Insulin Resistance and Diabetes in Chronic Renal Disease
30. Growth Hormone
31. Sexual Dysfunction in Men and Women with Chronic Kidney Disease
32. Thyroid Status in Chronic Renal Failure Patients - a Non-Thyroidal Illness Syndrome
33. Metabolic Acidosis of Chronic Kidney Disease - its role in progression
34. Pregnancy and the Kidney
35. Novel agents for the treatment of Pre-eclampsia

Produkt-Details

• Erscheint lt. Verlag: 1.6.2026
• Verlagsort: San Diego
• Sprache: englisch
• Maße: 216 x 276 mm
• Themenwelt: Naturwissenschaften ► Biologie
• ISBN-10: 0-443-21751-3 / 0443217513
• ISBN-13: 978-0-443-21751-7 / 9780443217517
• Zustand: Neuware