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Cortical Deficits in Schizophrenia

From Genes to Function

Patricio O'Donnell (Herausgeber)

Buch | Hardcover

239 Seiten

2007
Springer-Verlag New York Inc.
978-0-387-74350-9 (ISBN)

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The genetics of schizophrenia have taken the driver seat in the research - lated to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide pat- physiological scenarios that could link those cellular phenomena with sy- toms. In this book, we have chosen to elaborate on that link. The contributions to this book have been requested to reflect the current state of the connection between schizophrenia genetics and pathophysiology. The book opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes.

Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms.- Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function.- Homer: A Genetic Factor in Schizophrenia?.- Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia.- Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia.- A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia.- Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia.- Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications.- Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses.- Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences.- Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology.

Zusatzinfo	XIII, 239 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-387-74350-2 / 0387743502
ISBN-13	978-0-387-74350-9 / 9780387743509
Zustand	Neuware