Intentionally Infecting Humans
Is it Ethical?
Seiten
2026
Oxford University Press Inc (Verlag)
978-0-19-766789-7 (ISBN)
Oxford University Press Inc (Verlag)
978-0-19-766789-7 (ISBN)
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Intentionally Infecting Humans argues that ongoing ethical controversy about controlled human infection (CHI) research is fuelled by fundamental confusion, drawing on past uses and abuses of CHI, the experiences of volunteers, and social psychology research.
In controlled human infection (CHI) research, researchers intentionally expose people to pathogens to gain scientific insights. During the COVID-19 pandemic, proposals to use CHI research to speed up vaccine development captured public imagination and bioethicists’ attention, with more papers written on the ethics of CHI research than ever before.
Intentionally Infecting Humans: Is it Ethical? argues that ongoing ethical controversy about CHI research is fuelled by fundamental confusion. This book draws on past uses and abuses of CHI research, the experiences of volunteers, and social psychology research to help explain the status of these studies in the public imagination. It then provides an ethical framework for these studies, demonstrating that the biggest ethical challenge with this research is when scientists determine how to infect humans for the first time in a novel CHI model. Once a model has been shown to be safe and reliable, it is much less controversial to use CHI models in studies that can, for example, test new vaccines and treatments. Furthermore, given the time it takes to create a safe and reliable model, CHI research is not the "silver bullet" for vaccine development some promised during the COVID-19 pandemic but still may be a smart investment in the longer term. Distinguishing types of CHI research that raise more and less ethical concern also helps clarify when CHI research can be used by low- and middle-income countries embarking on new research programs, and for populations traditionally considered "vulnerable." The book leaves the reader with a richer understanding of the history that feeds into ongoing controversies over CHI research, ways that CHI research could be deployed ethically to enhance preparedness for future pandemics and address neglected diseases, and ideas to help resolve longstanding debates in research ethics more generally.
In controlled human infection (CHI) research, researchers intentionally expose people to pathogens to gain scientific insights. During the COVID-19 pandemic, proposals to use CHI research to speed up vaccine development captured public imagination and bioethicists’ attention, with more papers written on the ethics of CHI research than ever before.
Intentionally Infecting Humans: Is it Ethical? argues that ongoing ethical controversy about CHI research is fuelled by fundamental confusion. This book draws on past uses and abuses of CHI research, the experiences of volunteers, and social psychology research to help explain the status of these studies in the public imagination. It then provides an ethical framework for these studies, demonstrating that the biggest ethical challenge with this research is when scientists determine how to infect humans for the first time in a novel CHI model. Once a model has been shown to be safe and reliable, it is much less controversial to use CHI models in studies that can, for example, test new vaccines and treatments. Furthermore, given the time it takes to create a safe and reliable model, CHI research is not the "silver bullet" for vaccine development some promised during the COVID-19 pandemic but still may be a smart investment in the longer term. Distinguishing types of CHI research that raise more and less ethical concern also helps clarify when CHI research can be used by low- and middle-income countries embarking on new research programs, and for populations traditionally considered "vulnerable." The book leaves the reader with a richer understanding of the history that feeds into ongoing controversies over CHI research, ways that CHI research could be deployed ethically to enhance preparedness for future pandemics and address neglected diseases, and ideas to help resolve longstanding debates in research ethics more generally.
Seema K. Shah, JD, is Founder's Board Professor of Medical Ethics at Lurie Children's Hospital, Northwestern's Feinberg School of Medicine, and Pritzker School of Law (by courtesy). Shah's research focuses on pediatric and global health research ethics, particularly related to controlled human infection (CHI). Shah received a law degree from Stanford Law School and completed a bioethics fellowship at the National Institutes of Health (NIH). She was elected as a Hastings Center Fellow, chaired a panel on the ethics of Zika virus CHI research for NIH, and serves as an expert advisor to the World Health Organization on CHI research.
| Erscheint lt. Verlag | 20.5.2026 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 140 x 210 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Medizinethik |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| Studium ► Querschnittsbereiche ► Geschichte / Ethik der Medizin | |
| Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung | |
| Naturwissenschaften | |
| ISBN-10 | 0-19-766789-9 / 0197667899 |
| ISBN-13 | 978-0-19-766789-7 / 9780197667897 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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