Fundamentals of Biochemistry

Life at the Molecular Level

Donald Voet, Judith G. Voet, Charlotte W. Pratt (Autoren)

Buch | Hardcover

1240 Seiten

2008 | 3rd edition
John Wiley & Sons Inc (Verlag)
9780470129302 (ISBN)

Infos

Fundamentals of Biochemistry challenges readers to learn the chemical concepts that underlie both classical biochemical theory as well as the latest developments in the field. The third edition combines authoritative biochemical content with an accessible narrative and pedagogic style that greatly enhances learning.

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Voet, Voet, and Pratt’s Fundamentals of Biochemistry, challenges students to better understand the chemistry behind the biological structure and reactions occurring in living systems. The Third Edition continues this tradition, and additionally incorporates coverage of recent research and an expanded focus on preparing and supporting students throughout the course. With the addition of new conceptual assessment content to WileyPLUS, students have the opportunity to assess their conceptual understanding of key introductory biochemistry concepts and retrain themselves on their misconceptions.

Autor

Donald Voet received a B.S. in Chemistry from the California Institute of Technology, a Ph.D. in Chemistry from Harvard University with William Lipscomb, and did postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoctoral research, Don took up a faculty position in the Chemistry Department at the University of Pennsylvania where, for the past 38 years, he has taught a variety of Biochemistry courses as well as general Chemistry. His major area of research is the X-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, The University of California at San Diego, and the Weizmann Institute of Science in Israel. Together with Judith G. Voet, he is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. He is a member of the Education Committee of the International Union of Biochemistry and Molecular Biology. His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing Biochemistry textbooks. Judith ("Judy") Voet received her B.S. in Chemistry from Antioch College and her Ph.D. in Biochemistry from Brandeis University with Robert H. Abeles. She has done postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Her main area of research involves enzyme reaction mechanisms and inhibition. She taught Biochemistry at the University of Delaware before moving to Swarthmore College. She taught there for 26 years, reaching the position of James H. Hammons Professor of Chemistry and Biochemistry before going on "permanent sabbatical leave." She has been a visiting scholar at Oxford University, University of California, San Diego, University of Pennsylvania, and the Weizmann Institute of Science, Israel. She is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. She has been a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology as well as the Education Committee of the International Union of Biochemistry and Molecular Biology. Her hobbies include hiking, backpacking, scuba diving, and tap dancing. Charlotte Pratt received her B.S. in Biology from the University of Notre Dame and her Ph.D. in Biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that Biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral researching the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches at Seattle Pacific University. In addition to working as an editor of several Biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry.

Inhalt

Preface xviii

Acknowledgments xxi

Instructor and Student Resources xxiii

Guide to Media Resources xxv

PART I INTRODUCTION

1 Introduction to the Chemistry of Life 1

1 The Origin of Life 2

2 Cellular Architecture 5

3 Thermodynamics 11

E. Life Obeys the Laws of Thermodynamics 17

BOX 1-1 PATHWAYS OF DISCOVERY

BOX 1-2 PERSPECTIVES IN BIOCHEMISTRY

2 Water 22

1 Physical Properties of Water 23

2 Chemical Properties of Water 30

BOX 2-1 BIOCHEMISTRY IN HEALTH AND DISEASE

PART II BIOMOLECULES

3 Nucleotides, Nucleic Acids, and Genetic Information 39

1 Nucleotides 40

2 Introduction to Nucleic Acid Structure 43

3 Overview of Nucleic Acid Function 47

4 Nucleic Acid Sequencing 50

5 Manipulating DNA 59

BOX 3-1 PATHWAYS OF DISCOVERY

BOX 3-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 3-3 PERSPECTIVES IN BIOCHEMISTRY

4 Amino Acids 74

1 Amino Acid Structure 74

2 Stereochemistry 82

3 Amino Acid Derivatives 86

BOX 4-1 PATHWAYS OF DISCOVERY

BOX 4-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 4-3 PERSPECTIVES IN BIOCHEMISTRY

5 Proteins: Primary Structure 91

1 Polypeptide Diversity 91

2 Protein Purification and Analysis 94

3 Protein Sequencing 104

4 Protein Evolution 114

BOX 5-1 PATHWAYS OF DISCOVERY

6 Proteins:Three-Dimensional Structure 125

1 Secondary Structure 127

2 Tertiary Structure 140

3 Quaternary Structure and Symmetry 154

4 Protein Stability 156

5 Protein Folding 161

BOX 6-1 PATHWAYS OF DISCOVERY

BOX 6-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 6-3 PERSPECTIVES IN BIOCHEMISTRY

BOX 6-4 PERSPECTIVES IN BIOCHEMISTRY

7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies 176

1 Oxygen Binding to Myoglobin and Hemoglobin 177

2 Muscle Contraction 197

3 Antibodies 209

BOX 7-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 7-2 PATHWAYS OF DISCOVERY

BOX 7-3 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 7-4 PATHWAYS OF DISCOVERY

BOX 7-5 PERSPECTIVES IN BIOCHEMISTRY

8 Carbohydrates 219

1 Monosaccharides 220

2 Polysaccharides 226

3 Glycoproteins 234

BOX 8-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 8-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 8-3 BIOCHEMISTRY IN HEALTH AND DISEASE

9 Lipids and Biological Membranes 245

1 Lipid Classification 246

2 Lipid Bilayers 260

3 Membrane Proteins 263

4 Membrane Structure and Assembly 269

BOX 9-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 9-2 PATHWAYS OF DISCOVERY

BOX 9-3 BIOCHEMISTRY IN HEALTH AND DISEASE

10 Membrane Transport 295

1 Thermodynamics of Transport 296

2 Passive-Mediated Transport 297

3 Active Transport 311

BOX 10-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 10-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 10-3 BIOCHEMISTRY IN HEALTH AND DISEASE

PART III ENZYMES

11 Enzymatic Catalysis 322

1 General Properties of Enzymes 323

2 Activation Energy and the Reaction Coordinate 328

3 Catalytic Mechanisms 330

4 Lysozyme 339

5 Serine Proteases 347

BOX 11-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 11-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 11-3 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 11-4 BIOCHEMISTRY IN HEALTH AND DISEASE

12 Enzyme Kinetics, Inhibition, and Control 363

1 Reaction Kinetics 364

2 Enzyme Inhibition 377

3 Control of Enzyme Activity 386

4 Drug Design 394

BOX 12-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 12-2 PATHWAYS OF DISCOVERY

BOX 12-3 PERSPECTIVES IN BIOCHEMISTRY

BOX 12-4 BIOCHEMISTRY IN HEALTH AND DISEASE

13 Biochemical Signaling 405

1 Hormones 406

2 Receptor Tyrosine Kinases 412

3 Heterotrimeric G Proteins 428

4 The Phosphoinositide Pathway 436

BOX 13-1 PATHWAYS OF DISCOVERY

BOX 13-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 13-3 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 13-4 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 13-5 BIOCHEMISTRY IN HEALTH AND DISEASE

PART IV METABOLISM

14 Introduction to Metabolism 448

1 Overview of Metabolism 449

2 “High-Energy” Compounds 459

3 Oxidation–Reduction Reactions 469

4 Experimental Approaches to the Study of Metabolism 475

BOX 14-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 14-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 14-3 PATHWAYS OF DISCOVERY

BOX 14-4 PERSPECTIVES IN BIOCHEMISTRY

15 Glucose Catabolism 485

1 Overview of Glycolysis 486

2 The Reactions of Glycolysis 489

3 Fermentation:The Anaerobic Fate of Pyruvate 504

4 Regulation of Glycolysis 510

5 Metabolism of Hexoses Other than Glucose 516

6 The Pentose Phosphate Pathway 520

BOX 15-1 PATHWAYS OF DISCOVERY

BOX 15-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 15-3 PERSPECTIVES IN BIOCHEMISTRY

BOX 15-4 BIOCHEMISTRY IN HEALTH AND DISEASE

16 Glycogen Metabolism and Gluconeogenesis 530

1 Glycogen Breakdown 532

2 Glycogen Synthesis 540

3 Control of Glycogen Metabolism 545

4 Gluconeogenesis 552

5 Other Carbohydrate Biosynthetic Pathways 560

BOX 16-1 PATHWAYS OF DISCOVERY

BOX 16-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 16-3 PERSPECTIVES IN BIOCHEMISTRY

BOX 16-4 PERSPECTIVES IN BIOCHEMISTRY

17 Citric Acid Cycle 566

1 Overview of the Citric Acid Cycle 567

2 Synthesis of Acetyl-Coenzyme A 570

3 Enzymes of the Citric Acid Cycle 576

4 Regulation of the Citric Acid Cycle 583

5 Reactions Related to the Citric Acid Cycle 588

BOX 17-1 PATHWAYS OF DISCOVERY

BOX 17-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 17-3 PERSPECTIVES IN BIOCHEMISTRY

18 Electron Transport and Oxidative Phosphorylation 596

1 The Mitochondrion 597

2 Electron Transport 600

3 Oxidative Phosphorylation 618

4 Control of Oxidative Metabolism 631

BOX 18-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 18-2 PATHWAYS OF DISCOVERY

BOX 18-3 PERSPECTIVES IN BIOCHEMISTRY 

BOX 18-4 PERSPECTIVES IN BIOCHEMISTRY 

BOX 18-5 BIOCHEMISTRY IN HEALTH AND DISEASE

19 Photosynthesis 640

1 Chloroplasts 641

2 The Light Reactions 645

3 The Dark Reactions 663

BOX 19-1 PERSPECTIVES IN BIOCHEMISTRY

20 Lipid Metabolism 677

1 Lipid Digestion, Absorption, and Transport 678

2 Fatty Acid Oxidation 685

3 Ketone Bodies 698

4 Fatty Acid Biosynthesis 701

5 Regulation of Fatty Acid Metabolism 711

6 Synthesis of Other Lipids 714

7 Cholesterol Metabolism 721

BOX 20-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 20-2 PATHWAYS OF DISCOVERY 

BOX 20-3 PERSPECTIVES IN BIOCHEMISTRY

BOX 20-4 BIOCHEMISTRY IN HEALTH AND DISEASE

21 Amino Acid Metabolism 732

1 Protein Degradation 732

2 Amino Acid Deamination 738

3 The Urea Cycle 743

4 Breakdown of Amino Acids 747

5 Amino Acid Biosynthesis 763

6 Other Products of Amino Acid Metabolism 774

7 Nitrogen Fixation 782

BOX 21-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 21-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 21-3 BIOCHEMISTRY IN HEALTH AND DISEASE

22 Mammalian Fuel Metabolism: Integration and Regulation 791

1 Organ Specialization 792

2 Hormonal Control of Fuel Metabolism 799

3 Metabolic Homeostasis:The Regulation of Energy Metabolism, Appetite, and Body Weight 804

4 Disturbances in Fuel Metabolism 809

BOX 22-1 PATHWAYS OF DISCOVERY 

PART V GENE EXPRESSION AND REPLICATION

23 Nucleotide Metabolism 817

1 Synthesis of Purine Ribonucleotides 818

2 Synthesis of Pyrimidine Ribonucleotides 824

3 Formation of Deoxyribonucleotides 828

4 Nucleotide Degradation 839

BOX 23-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 23-2 PATHWAYS OF DISCOVERY

24 Nucleic Acid Structure 848

1 The DNA Helix 849

2 Forces Stabilizing Nucleic Acid Structures 864

3 Fractionation of Nucleic Acids 872

4 DNA–Protein Interactions 874

5 Eukaryotic Chromosome Structure 883

BOX 24-1 PATHWAYS OF DISCOVERY

BOX 24-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 24-3 PERSPECTIVES IN BIOCHEMISTRY

25 DNA Replication, Repair, and Recombination 893

1 Overview of DNA Replication 894

2 Prokaryotic DNA Replication 896

3 Eukaryotic DNA Replication 910

4 DNA Damage 916

5 DNA Repair 920

6 Recombination 926

BOX 25-1 PATHWAYS OF DISCOVERY

BOX 25-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 25-3 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 25-4 PERSPECTIVES IN BIOCHEMISTRY

BOX 25-5 PERSPECTIVES IN BIOCHEMISTRY

26 Transcription and RNA Processing 942

1 Prokaryotic RNA Transcription 943

2 Transcription in Eukaryotes 952

3 Posttranscriptional Processing 965

BOX 26-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 26-2 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 26-3 PATHWAYS OF DISCOVERY

27 Protein Synthesis 985

1 The Genetic Code 986

2 Transfer RNA and Its Aminoacylation 991

3 Ribosomes 1000

4 Translation 1008

5 Posttranslational Processing 1028

BOX 27-1 PERSPECTIVES IN BIOCHEMISTRY

BOX 27-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 27-3 BIOCHEMISTRY IN HEALTH AND DISEASE

28 Regulation of Gene Expression 1037

1 Genome Organization 1038

2 Regulation of Prokaryotic Gene Expression 1046

3 Regulation of Eukaryotic Gene Expression 1055

4 The Cell Cycle, Cancer, and Apoptosis 1081

BOX 28-1 BIOCHEMISTRY IN HEALTH AND DISEASE

BOX 28-2 PERSPECTIVES IN BIOCHEMISTRY

BOX 28-3 PERSPECTIVES IN BIOCHEMISTRY

APPENDICES

Solutions to Problems SP-1

Glossary G-1

Index I-1

Produkt-Details

• Erscheint lt. Verlag: 20.6.2008
• Verlagsort: New York
• Sprache: englisch
• Maße: 222 x 279 mm
• Gewicht: 2534 g
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• ISBN-13: 9780470129302 / 9780470129302
• Zustand: Neuware