Epigenetic Mechanisms in Brain Physiology and Disorders
Elsevier - Health Sciences Division (Verlag)
9780443190438 (ISBN)
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Dr. Szyf received his Ph.D. from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School, joined the McGill University in 1989 and currently holds a James McGill Professorship and GlaxoSmithKline-CIHR Chair in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Dr. Szyf has been the founder of the first “Pharma to develop epigenetic pharmacology “Methylgene Inc. and the first journal in epigenetics “Epigenetics. Szyf lab has proposed two decades ago that DNA methylation is a prime therapeutic target in cancer and other diseases and has postulated and provided the first set of evidence that the “social environment early in life can alter DNA methylation launching the emerging field of “social epigenetics. Zsofia Nemoda is an assistant professor at Semmelweis University in Budapest Hungary. She is a member of the Hungarian Biochemical Association, the International Society of Psychiatric Genetics, and the Hungarian Society of Human Genetics. She has 41 articles published in international journals with a cumulative impact factor of 168 and independent citations of 1139. In 2023 & 2024 she was affiliated the Douglas Mental Health University Institute, Montreal, Canada working with Dr. Linda Booij.
1. Introduction. Epigenetic mechanisms in brain function.
2. Evolution of epigenetic landscapes during pre and postnatal brain development and aging.
3. The role of DNA methylation and stepwise oxidation of 5 methylcytosine in epigenetic regulation of gene expression in the brain.
4. Learning and memory.
5. Stress and the HPA axis
6. Metabolic homeostasis
7. Puberty and sexual behavior
8. Body Temperature and thermal regulation
9. The role of epigenetic mechanism in the neuroimmune axis
10. The impact of genetic alterations in epigenetic proteins on brain disorders.
11. Epigenetic processes in neurodevelopmental disorders (RETT syndrome, Autism)
12. Linking early adversity epigenetics and neuropsychiatric disorders (psychosis)
13. Epigenetic processes in substance abuse, and behavioral addictions
14. Epigenetic processes in neurological diseases Alzheimer, Parkinson disease, Parkinson, ALS
15. Epigenetic mechanisms in chronic pain
16. Early life adversity trauma and PTSD linked by epigenetic mechanisms
17. Epigenetic mechanisms in brain aging, cognitive decline and dementia
18. Methodological challenges in epigenome wide associations with neuropsychiatry and behavioraldisorders
19. Animal models with construct validity for studying epigenetic processes in neurobehavior
20. Using epigenetic editing and to examine the role of site specific DNA methylation and oxidationalterations in neuroepigenetics.
21. Methods for dissecting cell neuron/glia/astrocyte specific patterns of methylationIPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders
| Erscheint lt. Verlag | 1.5.2026 |
|---|---|
| Verlagsort | Philadelphia |
| Sprache | englisch |
| Maße | 216 x 276 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-13 | 9780443190438 / 9780443190438 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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