Artificial Self-Assembling Systems for Gene Delivery

Philip L. Felgner, Michael J. Heller, Pierre Lehn, Jean-Paul Behr, Francis C. Szoka (Herausgeber)

Buch | Hardcover

208 Seiten

1996
American Chemical Society (Verlag)
978-0-8412-3415-4 (ISBN)

Infos

Discusses recent advances in artificial self-assembling systems, including retrotransposon vectors, hairpin ribozymes, triple-helix-forming oligonucleotides, liposome-mediated transfection, and photonic nanostructures. Addresses developing efficient synthetic vectors such as modular self-assembling systems mimicking important features of viral vectors. Presents new developments in synthetic self-assembling gene delivery systems, including innovations in nonviral
systems, targeting nucleic acids, ligand-polylysine mediated transfer, dendrimer-mediated transfection, cationic liposomes, and polylysine DNA complexes.

Inhalt

Synthetic Retrotransposon Vectors and Gene Targeting ; A New Retroviral Vector and a New Method To Target Homologous Recombination in Mammalian Cells ; Development of the Hairpin Ribozyme as a Gene Therapy Approach to Human Immunodeficiency Virus Type-1 Infection ; Replicating Plasmid Vectors for Cancer Gene Therapy ; Gene Targeting Using Triple-Helix-Forming Oligonucleotides ; Effects of Lipololysaccahrides on Liposome-Mediated Transfection and the Consequence for DNA Preparation for Gene Therapy ; The Application of Electronic Pulse Delivery in Gene Therapy: Progress and Perspectives ; Self-Assembling DNA Photonic Nanostructures ; Controllable Gene Therapy Using Nonviral Systems ; Progress in Targeting Nucleic Acids to the Liver ; Advances in Receptor-Mediated Gene Transfer into Cells In Vitro and In Vivo ; Ligand-Polylysine Mediated Gene Transfer ; Efficient Transfer of Genetic Material into Mammalian Cells Using Polyamidoamine Dendrimers as Synthetic Vectors: Dendrimer-Mediated Transfection ; The Proton Sponge: A Trick the Viruses Did Not Exploit ; Biomaterials for Gene Transfer: Self-Assembling Nanostructured Aquasomes ; Gene Transfer by Liposome-Entrapped Polycation-Condensed DNA: LPDI and LPDII ; Gene Transfer into Mammalian Cells Using Synthetic Cationic Lipids

Produkt-Details

• Reihe/Serie: ACS Conference Proceedings Series
• Verlagsort: Washington
• Sprache: englisch
• Maße: 156 x 234 mm
• Gewicht: 419 g
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• ISBN-10: 0-8412-3415-9 / 0841234159
• ISBN-13: 978-0-8412-3415-4 / 9780841234154
• Zustand: Neuware