Alternative Splicing

Recent Advances in Health and Disease

Sayeed ur Rehman A. Kalam, Mohammad Tabish (Herausgeber)

Buch | Softcover

350 Seiten

2026
Academic Press Inc (Verlag)
978-0-443-30274-9 (ISBN)

Infos

Alternative Splicing: Recent Advances in Health and Disease offers a comprehensive study of this cellular process, its fundamental characteristics, latest advances and clinical utilization. Opening with an introduction to alternative splicing and its function in generating transcriptome and protein diversity, the book considers the role of this process across a range of diseases and disorders, including cardiovascular disease, cancer, obesity, and viral infections. Key methods used to study alternative splicing are also investigated, including high-throughput sequencing-based methods, bioinformatics tools, computational methods, single-cell sequencing techniques and mass-spectrometry based proteomics. This is followed with analysis of therapeutic approaches associated with alternative splicing. This is an ideal reference for those involved in investigating alternative splicing and its impact to health and disease, and is therefore relevant to researchers across cell biology, molecular biology, pharmacology and related areas.

Autor

Dr. Sayeed ur Rehman is an Assistant Professor in the Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India. Dr. Rehman and his team are working to decipher the role of alternative splicing in health and disease. They are currently involved in the identification and characterization of alternatively spliced novel isoforms of human genes linked to cancer, obesity and diabetes, neurodegenerative disorders and genes linked to host-pathogen interactions. Dr. Rehman has also worked as Leibniz-DAAD Fellow at the German Diabetes Centre, Dusseldorf, Germany. He has around 8 years of teaching and research experience and has published around 45 research and review articles in the field of study. Professor Mohammad Tabish completed his Ph.D. from Japan and is currently working in the Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India. He has obtained post-doctoral training in different institutes including the Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas, USA., School of Biological Sciences, University of Liverpool, UK., Karolinska Institute, Stockholm, Sweden., Toyohashi University of Technology, Toyohashi, Aichi, Japan and University of Connecticut Health Center, Farmington, Connecticut, USA. He has over 25 years of teaching and research experience in the field of biotechnology, molecular biology, and bioinformatics. Professor Tabish has published several research and review articles in the field of molecular biology with special emphasis on alternative splicing. He has also received several prestigious fellowships including NIH funded fellowships, Wennergren fellowship, Leverhulme Trust visiting fellowship and Japanese Government fellowship (Monbusho) for Ph.D. at Toyohashi University of Technology, Toyohashi, Japan.

Inhalt

1. Alternative splicing: Introduction
2. Alternative splicing and cardiovascular diseases
3. Alternative splicing and cancer
4. Alternative splicing and obesity/diabetes
5. Alternative splicing and bacterial infections
6. Alternative splicing and fungal pathogenesis
7. Alternative splicing and viral infections
8. Alternative splicing and other disorders
9. Integrative multiomics: An approach to understanding alternative splicing
10. Recent therapeutic approaches involving alternative splicing
11. Splice-switching strategies for neurodegenerative diseases

Produkt-Details

• Erscheint lt. Verlag: 1.11.2026
• Verlagsort: San Diego
• Sprache: englisch
• Maße: 191 x 235 mm
• Gewicht: 450 g
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• ISBN-10: 0-443-30274-X / 044330274X
• ISBN-13: 978-0-443-30274-9 / 9780443302749
• Zustand: Neuware