Characterizing Biotherapeutics (eBook)
1326 Seiten
Wiley (Verlag)
978-1-394-23612-1 (ISBN)
Provides detailed and up-to-date coverage of analytical approaches for biologic drug modalities
The development of innovative biologic therapies has revolutionized medicine, but their complexity demands equally advanced analytical approaches. Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities introduces the tools and techniques used to analyze these groundbreaking therapies. Designed to help readers characterize and troubleshoot increasingly diverse and sophisticated therapeutic molecules, this in-depth guide addresses different biologic drugs, their unique analytical challenges, and the methods that enable their analysis.
Organized into two comprehensive sections, Characterizing Biotherapeutics first delves into the fundamentals of analytical platforms, providing a robust foundation in techniques such as mass spectrometry and biophysical assays. The second section applies these methods to real-world scenarios, focusing on drug discovery, clinical evaluation, and commercial considerations in drug development. Authors Jennie R. Lill and Wendy Sandoval provide clear guidance tailored to the evolving demands of therapeutic innovations such as structural characterization, high-throughput biophysical assays, and RNA-based therapeutics.
Equipping researchers with the knowledge to navigate the challenges posed by increasingly complex biologics, Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities:
- Discusses new and emerging biological molecule diversity and both traditional analytical methods
- Provides characterization strategies for large molecule (protein/antibody) based therapeutics
- Summarizes cutting-edge technologies for novel modalities and antibody protein therapeutics
- Incorporates the latest advancements in mass spectrometry, functional assays, and biophysical methods
- Addresses specialized analytical issues for membrane proteins and other challenging targets
- Presents methodologies for assessing safety and therapeutic potential
Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities is an essential reference for analytical scientists, biologists, and mass spectrometrists involved in biomolecule analysis. It is also a valuable resource for graduate students taking advanced courses in biotechnology, drug development, and biotherapeutic analysis, as well as professionals in biotechnology and pharmaceutical industries working to advance biotherapeutic research and development.
Jennie R. Lill, PhD, is the Executive Director of the Proteomic and Genomic Technologies Department at Genentech, where she has worked since 2004. With over 90 peer-reviewed publications and three books, including Analytical Characterization of Biotherapeutics, her work focuses on cutting-edge analytical techniques in drug discovery and development.
Wendy Sandoval was the Director of Translational Mass Spectrometry in Research at Genentech, where she had been a pivotal contributor for over 30 years. She has authored more than 100 scientific publications and co-authored two books, including Analytical Characterization of Biotherapeutics. She now runs a plant nursery and botanical garden in Northern California (https://botanicanurseryandgardens.com/) and enjoys playing in dirt.
Provides detailed and up-to-date coverage of analytical approaches for biologic drug modalities The development of innovative biologic therapies has revolutionized medicine, but their complexity demands equally advanced analytical approaches. Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities introduces the tools and techniques used to analyze these groundbreaking therapies. Designed to help readers characterize and troubleshoot increasingly diverse and sophisticated therapeutic molecules, this in-depth guide addresses different biologic drugs, their unique analytical challenges, and the methods that enable their analysis. Organized into two comprehensive sections, Characterizing Biotherapeutics first delves into the fundamentals of analytical platforms, providing a robust foundation in techniques such as mass spectrometry and biophysical assays. The second section applies these methods to real-world scenarios, focusing on drug discovery, clinical evaluation, and commercial considerations in drug development. Authors Jennie R. Lill and Wendy Sandoval provide clear guidance tailored to the evolving demands of therapeutic innovations such as structural characterization, high-throughput biophysical assays, and RNA-based therapeutics. Equipping researchers with the knowledge to navigate the challenges posed by increasingly complex biologics, Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities: Discusses new and emerging biological molecule diversity and both traditional analytical methods Provides characterization strategies for large molecule (protein/antibody) based therapeutics Summarizes cutting-edge technologies for novel modalities and antibody protein therapeutics Incorporates the latest advancements in mass spectrometry, functional assays, and biophysical methods Addresses specialized analytical issues for membrane proteins and other challenging targets Presents methodologies for assessing safety and therapeutic potential Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities is an essential reference for analytical scientists, biologists, and mass spectrometrists involved in biomolecule analysis. It is also a valuable resource for graduate students taking advanced courses in biotechnology, drug development, and biotherapeutic analysis, as well as professionals in biotechnology and pharmaceutical industries working to advance biotherapeutic research and development.
List of Contributors
Corey E. Bakalarski
Proteomic and Genomic Technologies
Genentech Inc.
South San Francisco, CA
USA
Mercedesz Balasz
Biochemical and Cellular Pharmacology
Genentech
South San Francisco
CA, USA
Marcus Bantscheff
Target Discovery, GSK
Heidelberg
Germany
and
Research and Early Development
Roche Pharma
Basel
Switzerland
Hayley M. Bennett
Department of Proteomic and Genomic Technologies
Genentech Research and Early Development
South San Francisco, CA
USA
Maureen Beresini
Department of Biochemical and Cellular Pharmacology
Genentech Inc.
South San Francisco, CA
USA
Tess Branon
Proteomic & Genomic Technologies Department
Genentech Inc.
South San Francisco, CA
USA
Ashley Byrne
Department of Proteomic and Genomic Technologies
Genentech Research and Early Development
South San Francisco, CA
USA
Julien Camperi
Cell Therapy Engineering and Development
Genentech
South San Francisco, CA
USA
Shengya Cao
Development
Inceptive
Palo Alto, CA
USA
Naincy R. Chandan
Discovery Technology
Nurix Therapeutics, Inc.
San Francisco, CA
USA
Jieming Chen
gRED Computational Sciences
Genentech
South San Francisco, CA
USA
Sivan Cohen
Bioanalytical Sciences
Genentech, Inc.
South San Francisco, CA
USA
Phillip Chu
Genentech, Inc.
South San Francisco, CA
USA
Michael Dillon
Department of Antibody Engineering
Genentech Research and Early Development
South San Francisco, CA
USA
H. Christian Eberl
Target Discovery, GSK
Heidelberg
Germany
Alberto Estevez
Thomson Instrument Company
Carlsbad, CA
USA
Amin Famili
Department of Synthetic Molecule Analytical Chemistry
Genentech
South San Francisco, CA
USA
Abel Ferrel
Independent Researcher
San Francisco, CA
USA
Emily Freund
Department of Molecular Biology
Genentech
South San Francisco, CA
USA
Manasi Gaikwad
Center for Mass Spectrometry and Optical Spectroscopy (CeMOS)
Mannheim University of Applied Sciences
Mannheim
Germany
Carolina Galan
Department of Molecular Biology
Genentech
South San Francisco, CA
USA
Amy Gilbert
Adaptive Biotechnologies
Seattle, WA
USA
Alissa D. Guarnaccia
Department of Proteomic and Genomic Technologies
Genentech
South San Francisco, CA
USA
and
Proteomic and Genomic Technologies
Genentech Inc.
South San Francisco, CA
USA
Axel Guilbaud
Protein Analytical Chemistry
Genentech
South San Francisco, CA
USA
Albert J.R. Heck
Biomolecular Mass Spectrometry and Proteomics
Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
University of Utrecht
Utrecht
The Netherlands
and
Netherlands Proteomics Center
Utrecht
The Netherlands
Suk‐Joon Hyung
Genentech, Inc.
South San Francisco, CA
USA
Saeed Izadi
Pharmaceutical Development
Genentech Inc.
South San Francisco, CA
USA
Eric Janezic
Biochemical and Cellular Pharmacology
Genentech Inc.
South San Francisco, CA
USA
Christine C. Jao
Department of Structural Biology
Genentech Inc.
South San Francisco, CA
USA
Hiruni S. Jayasekera
Department of Chemistry and Biochemistry
The University of Arizona
Tucson, AZ
USA
Robert S. Jones
Drug Metabolism and Pharmokinetics
Genentech, Inc.
South San Francisco, CA
USA
S. Cyrus Khojasteh
Genentech, Inc.
South San Francisco, CA
USA
Sascha Knecht
Target Discovery, GSK
Heidelberg
Germany
Felix Kuhne
Analytical Characterization, Pharma Technical Development
Roche Diagnostics GmbH
Penzberg
Germany
M. Violet Lee
Bioanalytical Sciences
Genentech
South San Francisco, CA
USA
Paola Di Lello
Department of Structural Biology
Genentech, Inc.
South San Francisco, CA
USA
Dennis H. Leung
Genentech, Inc.
South San Francisco, CA
USA
Amritha Lewis
Adaptive Biotechnologies
Seattle, WA
USA
Yinyin Li
Biochemical and Cellular Pharmacology
Genentech
South San Francisco, CA
USA
Jennie R. Lill
Department of Proteomic and Genomic Technologies
Genentech
South San Francisco, CA
USA
and
Proteomic and Genomic Technologies
Genentech Inc.
South San Francisco, CA
USA
and
Proteomic and Genomic Technologies
Genentech
South San Francisco, CA
USA
Rachel P. Liu
Protein Analytical Chemistry
Genentech Inc.
South San Francisco, CA
USA
T. Noelle Lombana
Department of Antibody Engineering
Genentech Research and Early Development
South San Francisco, CA
USA
and
ReCode Therapeutics
Menlo Park, CA
USA
Kelly Loyet
Department of Biochemical and Cellular Pharmacology
Genentech Inc.
South San Francisco, CA
USA
Patrick Lupardus
Department of Structural Biology
Genentech, Inc.
South San Francisco, CA
USA
Bin Ma
Genentech, Inc.
South San Francisco, CA
USA
Michael T. Marty
Department of Chemistry and Biochemistry
The University of Arizona
Tucson, AZ
USA
Rebecca Melmon
Adaptive Biotechnologies
Seattle, WA
USA
Madyson Migliozzi
Department of Pharmaceutical Development
Genentech
South San Francisco, CA
USA
Zora Modrusan
Department of Proteomic and Genomic Technologies
Genentech Research and Early Development
South San Francisco, CA
USA
Farhana Afrin Mohona
Department of Chemistry and Biochemistry
The University of Arizona
Tucson, AZ
USA
Huy Nguyen
Genentech, Inc.
South San Francisco, CA
USA
Emma Pelegri‐O'Day
Amgen Research, Amgen Inc.
South San Francisco, CA
USA
Qui T. Phung
Proteomic and Genomic Technologies
Genentech
South San Francisco, CA
USA
Emile Plise
Genentech, Inc.
South San Francisco, CA
USA
Markus A. Queisser
Modality Platform Technologies, GSK
Medicines Research Centre
Stevenage
UK
Roshan M. Regy
Pharmaceutical Development
Genentech Inc.
South San Francisco, CA
USA
Amber D. Rolland
Biomolecular Mass Spectrometry and Proteomics
Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
University of Utrecht
Utrecht
The Netherlands
and
Netherlands Proteomics Center
Utrecht
The Netherlands
Ola M. Saad
Genentech, Inc.
South San Francisco, CA
USA
and
Bioanalytical Sciences
Genentech
South San Francisco, CA
USA
Sudeshna Sadhu
Adaptive...
| Erscheint lt. Verlag | 6.6.2025 |
|---|---|
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Chemie ► Organische Chemie |
| Schlagworte | biologic characterization techniques • biotherapeutics • biotherapeutics analytical methods • biotherapeutics characterization • biotherapeutics characterization, mass spectrometry biotherapeutics • cell therapies analysis • drug discovery analytical methods • mass spectrometry biotherapeutics • RNA therapeutics analysis |
| ISBN-10 | 1-394-23612-3 / 1394236123 |
| ISBN-13 | 978-1-394-23612-1 / 9781394236121 |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
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