Simulating Protein Folding in Variable Environmental Conditions

Transformation from Globular Proteins to Amyloids

Buch | Softcover

350 Seiten

2026
Elsevier - Health Sciences Division (Verlag)
978-0-443-40475-7 (ISBN)

Noch nicht erschienen (ca. Januar 2026)
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Simulating Protein Folding in Variable Environmental Conditions: Transformation from Globular Proteins to Amyloids delves into the effects of external conditions upon the protein folding process. The book considers how this can lead to amyloid formation and why proteins fold the way they do. It presents the fuzzy oil drop model (FOD-M), which enables the measurements of external factors influencing the folding process and considers changed external conditions as the source for the misfolding process. Sections provide an introduction to amyloid transformation and outline the hypothesis of the model simulation before considering the role of environmental factors, including the water environment and membrane environment.

This book is a useful resource for researchers interested in investigating protein folding across molecular biology, structural biology, biochemistry, computational biology and related fields.

Professor Irena Roterman-Konieczna completed her PhD at the Nicolaus Copernicus Medical Academy Krakow, Poland and undertook her postdoctoral studies at Cornell University, USA. She is the director of the Department of Bioinformatics and Telemedicine at Jagiellonian University – Medical College, Poland. Her fields of interest are protein structure, folding simulation as well as systems biology. She is the author of "Protein Folding in Silico", published by Woodhead Publishing in 2012., and "From Globular Proteins to Amyloids" published by Elsevier in 2020. She is the Chief Editor of the journal Bio-Algorithms and Med-Systems (de Gruyter).

Part I: The amyloid transformation
1. The hypothesis - the biochemistry of amyloids
2. Three examples of different scenarios of amyloid transformation

Part II: Role of local environment in proteins structurization
3. Water environment
4. Membrane environment
5. General universal form to express the external force field

Part III: Local environment representation in programs oriented on protein structure prediction
6. Presentation of protocol for In Silico folding simulation Part IV: Specificity of secondary structure in amyloids
7. Analysis of secondary structure specificity as it appears in amyloids

Part V: The complete spectrum of environment influence (external force field) on protein folding
8. The examples of protein representing the micelle-like construction
9. The examples of proteins with participation of external force field in moderate degree
10. The trans-membrane proteins as examples of high influence of local environment on protein structurization
11. Enzymes – their protein body - as objects delivering the local external force field for catalytic reaction
12. Folding in assistance of chaperonin, chaperon, prefoldin – analysis as expressed by FOD-M model

Part VI: Alternative models for amyloid interpretation
13. Alternative models

Erscheint lt. Verlag	30.1.2026
Verlagsort	Philadelphia
Sprache	englisch
Maße	152 x 229 mm
Gewicht	450 g
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-443-40475-5 / 0443404755
ISBN-13	978-0-443-40475-7 / 9780443404757
Zustand	Neuware